Zoledronic acid induces a significant decrease of circulating endothelial cells and circulating endothelial precursor cells in the early prostate cancer neoadjuvant setting

Antonio Russo, Giuseppe Cicero, Francesco Pantano, Federico Sergi, Alice Zoccoli, Michele Iuliani, Melania Di Cerbo, Chiara Gregorj, Maurizio Buscarini, Gerardo Flammia, Rita Zamarchi, Bruno Vincenzi, Giuseppe Avvisati, Giuseppe Tonini, Daniele Santini, Daniele Santini, Sergio Rizzo

Risultato della ricerca: Articlepeer review

9 Citazioni (Scopus)

Abstract

Purpose: Published data demonstrated that zoledronic acid (ZOL) exhibits antiangiogenetic effects. A promising tool for monitoring antiangiogenic therapies is the measurement of circulating endothelial cells (CECs) and circulating endothelial precursor cells (CEPs) in the peripheral blood of patients. Our aim was to investigate the effects of ZOL on levels of CECs and CEPs in localized prostate cancer. Methods: Ten consecutive patients with a histologic diagnosis of low-risk prostate adenocarcinoma were enrolled and received an intravenous infusion of ZOL at baseline (T0), 28 days (T28) and 56 days (T56). Blood samples were collected at the following times: T0 (before the first infusion of ZOL), T3 (72 h after the first dose), T28, T56 (both just before the ZOL infusion) and T84 (28 days after the last infusion of ZOL) and CEC/CEP levels were directly quantified by flow cytometry at all these time points. Results: Our analyses highlighted a significant reduction of mean percentage of CECs and CEPs after initiation of ZOL treatment [p = 0.014 (at day 3) and p = 0.012 (at day 84), respectively]. Conclusion: These preliminary results demonstrate that ZOL could exert an antiangiogenic effect in early prostate cancer through CEP and CEC modulation.
Lingua originaleEnglish
pagine (da-a)342-347
Numero di pagine6
RivistaOncology
Volume85
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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