Zebrafish as a Model for the Study of Chaperonopathies

Francesco Cappello, Federica Scalia, Gianfranco Bellipanni, Francesco Cappello, Everly Conway De Macario, Alberto J.L. Macario, Antonio Giordano, Antonio Giordano

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

There is considerable information on the clinical manifestations and mode of inheritance for many genetic chaperonopathies but little is known on the molecular mechanisms underlying the cell and tissue abnormalities that characterize them. This scarcity of knowledge is mostly due to the lack of appropriate animal models that mimic closely the human molecular, cellular, and histological characteristics. In this article we introduce zebrafish as a suitable model to study molecular and cellular mechanisms pertaining to human chaperonopathies. Genetic chaperonopathies manifest themselves from very early in life so it is necessary to examine the impact of mutant chaperone genes during development, starting with fertilization and proceeding throughout the entire ontogenetic process. Zebrafish is amenable to such developmental analysis as well as studies during adulthood. In addition, the zebrafish genome contains a wide range of genes encoding proteins similar to those that form the chaperoning system of humans. This, together with the availability of techniques for genetic manipulations and for examination of all stages of development, makes zebrafish the organism of choice for the analysis of the molecular features and pathogenic mechanisms pertaining to human chaperonopathies. J. Cell. Physiol. 9999: 1-8, 2016.
Lingua originaleEnglish
pagine (da-a)2107-14-2114
Numero di pagine8
RivistaJournal of Cellular Physiology
Volume231
Stato di pubblicazionePublished - 2016

Fingerprint

Zebrafish
Genes
Gene encoding
Animals
Availability
Tissue
Genetic Techniques
Fertilization
Proteins
Animal Models
Genome

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cita questo

Cappello, F., Scalia, F., Bellipanni, G., Cappello, F., Conway De Macario, E., Macario, A. J. L., ... Giordano, A. (2016). Zebrafish as a Model for the Study of Chaperonopathies. Journal of Cellular Physiology, 231, 2107-14-2114.

Zebrafish as a Model for the Study of Chaperonopathies. / Cappello, Francesco; Scalia, Federica; Bellipanni, Gianfranco; Cappello, Francesco; Conway De Macario, Everly; Macario, Alberto J.L.; Giordano, Antonio; Giordano, Antonio.

In: Journal of Cellular Physiology, Vol. 231, 2016, pag. 2107-14-2114.

Risultato della ricerca: Article

Cappello, F, Scalia, F, Bellipanni, G, Cappello, F, Conway De Macario, E, Macario, AJL, Giordano, A & Giordano, A 2016, 'Zebrafish as a Model for the Study of Chaperonopathies', Journal of Cellular Physiology, vol. 231, pagg. 2107-14-2114.
Cappello F, Scalia F, Bellipanni G, Cappello F, Conway De Macario E, Macario AJL e altri. Zebrafish as a Model for the Study of Chaperonopathies. Journal of Cellular Physiology. 2016;231:2107-14-2114.
Cappello, Francesco ; Scalia, Federica ; Bellipanni, Gianfranco ; Cappello, Francesco ; Conway De Macario, Everly ; Macario, Alberto J.L. ; Giordano, Antonio ; Giordano, Antonio. / Zebrafish as a Model for the Study of Chaperonopathies. In: Journal of Cellular Physiology. 2016 ; Vol. 231. pagg. 2107-14-2114.
@article{67e2ca5866ee43c3b5dcbcebc91628d7,
title = "Zebrafish as a Model for the Study of Chaperonopathies",
abstract = "There is considerable information on the clinical manifestations and mode of inheritance for many genetic chaperonopathies but little is known on the molecular mechanisms underlying the cell and tissue abnormalities that characterize them. This scarcity of knowledge is mostly due to the lack of appropriate animal models that mimic closely the human molecular, cellular, and histological characteristics. In this article we introduce zebrafish as a suitable model to study molecular and cellular mechanisms pertaining to human chaperonopathies. Genetic chaperonopathies manifest themselves from very early in life so it is necessary to examine the impact of mutant chaperone genes during development, starting with fertilization and proceeding throughout the entire ontogenetic process. Zebrafish is amenable to such developmental analysis as well as studies during adulthood. In addition, the zebrafish genome contains a wide range of genes encoding proteins similar to those that form the chaperoning system of humans. This, together with the availability of techniques for genetic manipulations and for examination of all stages of development, makes zebrafish the organism of choice for the analysis of the molecular features and pathogenic mechanisms pertaining to human chaperonopathies. J. Cell. Physiol. 9999: 1-8, 2016.",
author = "Francesco Cappello and Federica Scalia and Gianfranco Bellipanni and Francesco Cappello and {Conway De Macario}, Everly and Macario, {Alberto J.L.} and Antonio Giordano and Antonio Giordano",
year = "2016",
language = "English",
volume = "231",
pages = "2107--14--2114",
journal = "Journal of Cellular Physiology",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Zebrafish as a Model for the Study of Chaperonopathies

AU - Cappello, Francesco

AU - Scalia, Federica

AU - Bellipanni, Gianfranco

AU - Cappello, Francesco

AU - Conway De Macario, Everly

AU - Macario, Alberto J.L.

AU - Giordano, Antonio

AU - Giordano, Antonio

PY - 2016

Y1 - 2016

N2 - There is considerable information on the clinical manifestations and mode of inheritance for many genetic chaperonopathies but little is known on the molecular mechanisms underlying the cell and tissue abnormalities that characterize them. This scarcity of knowledge is mostly due to the lack of appropriate animal models that mimic closely the human molecular, cellular, and histological characteristics. In this article we introduce zebrafish as a suitable model to study molecular and cellular mechanisms pertaining to human chaperonopathies. Genetic chaperonopathies manifest themselves from very early in life so it is necessary to examine the impact of mutant chaperone genes during development, starting with fertilization and proceeding throughout the entire ontogenetic process. Zebrafish is amenable to such developmental analysis as well as studies during adulthood. In addition, the zebrafish genome contains a wide range of genes encoding proteins similar to those that form the chaperoning system of humans. This, together with the availability of techniques for genetic manipulations and for examination of all stages of development, makes zebrafish the organism of choice for the analysis of the molecular features and pathogenic mechanisms pertaining to human chaperonopathies. J. Cell. Physiol. 9999: 1-8, 2016.

AB - There is considerable information on the clinical manifestations and mode of inheritance for many genetic chaperonopathies but little is known on the molecular mechanisms underlying the cell and tissue abnormalities that characterize them. This scarcity of knowledge is mostly due to the lack of appropriate animal models that mimic closely the human molecular, cellular, and histological characteristics. In this article we introduce zebrafish as a suitable model to study molecular and cellular mechanisms pertaining to human chaperonopathies. Genetic chaperonopathies manifest themselves from very early in life so it is necessary to examine the impact of mutant chaperone genes during development, starting with fertilization and proceeding throughout the entire ontogenetic process. Zebrafish is amenable to such developmental analysis as well as studies during adulthood. In addition, the zebrafish genome contains a wide range of genes encoding proteins similar to those that form the chaperoning system of humans. This, together with the availability of techniques for genetic manipulations and for examination of all stages of development, makes zebrafish the organism of choice for the analysis of the molecular features and pathogenic mechanisms pertaining to human chaperonopathies. J. Cell. Physiol. 9999: 1-8, 2016.

UR - http://hdl.handle.net/10447/198955

UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4652

M3 - Article

VL - 231

SP - 2107-14-2114

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

SN - 0021-9541

ER -