Women and peripheral arterial disease: same disease, different issues

Salvatore Novo, Massimo Chiariello, Gregorio Brevetti, Elio Melillo, Roxana Bucur, Alberto Balbarini, Ida Maria Muratori

    Risultato della ricerca: Articlepeer review

    44 Citazioni (Scopus)


    Objectives Atherosclerosis is a multifactorial disease and, thus, its clinical manifestations are likely to present gender-specific differences with respect to their development, course, symptom complexes and prognosis. The present study aimed to examine sex differences in peripheral arterial disease (PAD) and its clinical correlates.Methods PAD severity, quality of life (assessed by ST-22), cardiovascular risk factors, inflammatory profile and comorbidity were assessed in 163 men and 68 women who were consecutively diagnosed with PAD at three Italian University vascular centres.Results Compared to men, women showed a higher prevalence of critical limb ischemia (P = 0.018), but had a less impaired quality of life (assessed by ST-22), and were less likely to have a history of lower extremity revascularization. Furthermore, women tended to be older (P = 0.058), and more likely to present hypercholesterolemia (P = 0.053), diabetes mellitus (P = 0.001), body mass index >= 30 kg/m(2) (P = 0.003) and metabolic syndrome (P = 0.001). Conversely, C-reactive protein plasma levels were similar in the two groups. No gender-specific difference was observed in cardiovascular comorbidity; however, the condition showing the strongest association with coronary artery disease was diabetes mellitus in women (odds ratio = 4.96, P = 0.021), and smoking in men (odds ratio = 2.66, P = 0.008).Conclusion In PAD, there are several sex differences in baseline characteristics, especially with respect to the weight and significance of cardiovascular risk factors. Knowledge of these differences may help achieve optimal gender-specific cardiovascular risk prevention.
    Lingua originaleEnglish
    pagine (da-a)382-388
    Numero di pagine7
    RivistaJournal of Cardiovascular Medicine
    Stato di pubblicazionePublished - 2008

    All Science Journal Classification (ASJC) codes

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