TY - JOUR
T1 - Whole grain consumption and human health: an umbrella review of observational studies
AU - Buscemi, Silvio
AU - Alonzo, Elena
AU - Titta, Lucilla
AU - Beck, Eleanor
AU - Grosso, Giuseppe
AU - Marventano, Stefano
AU - Vetrani, Claudia
AU - Lafranconi, Alessandra
AU - Vitale, Marilena
AU - Godos, Justyna
AU - Ghelfi, Francesca
AU - Del Rio, Daniele
AU - Grosso, Giuseppe
AU - Tieri, Maria
AU - Gambera, Angelo
AU - Galvano, Fabio
AU - Sciacca, Salvatore
AU - Riccardi, Gabriele
AU - Ray, Sumantra
PY - 2020
Y1 - 2020
N2 - Whole grains have been associated with a number of health benefits. We systematically reviewed existing meta-analyses of observational studies and evaluated the level of evidence for their putative effects based on pre-selected criteria. Of the 23 included studies, we found convincing evidence of an inverse association between whole grain consumption and risk of type-2 diabetes and colorectal cancer; possible evidence of decreased risk of colon cancer and cardiovascular mortality with increased whole grain intake, as well as increased risk of prostate cancer. Limited or insufficient evidence was available for all other outcomes investigated. Overall findings are encouraging for a positive effect of whole grain consumption on certain diseases, especially highly prevalent metabolic diseases, however, uncertainty of some negative associations deserves further attention.
AB - Whole grains have been associated with a number of health benefits. We systematically reviewed existing meta-analyses of observational studies and evaluated the level of evidence for their putative effects based on pre-selected criteria. Of the 23 included studies, we found convincing evidence of an inverse association between whole grain consumption and risk of type-2 diabetes and colorectal cancer; possible evidence of decreased risk of colon cancer and cardiovascular mortality with increased whole grain intake, as well as increased risk of prostate cancer. Limited or insufficient evidence was available for all other outcomes investigated. Overall findings are encouraging for a positive effect of whole grain consumption on certain diseases, especially highly prevalent metabolic diseases, however, uncertainty of some negative associations deserves further attention.
UR - http://hdl.handle.net/10447/480045
M3 - Article
VL - 71
SP - 668
EP - 677
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
SN - 0963-7486
ER -