Whole cow’s milk but not lactose can induce symptoms in patients with self‐reported milk intolerance: evidence of cow’s milk sensitivity in adults

Ada Maria Florena, Pasquale Mansueto, Antonio Carroccio, Maurizio Soresi, Francesca Fayer, Alberto D’Alcamo, Antonio Carroccio, Aurelio Seidita, Francesco La Blasca, Chiara Garlisi, Beatrice Mantia, Chiara Tinè, Pasquale Mansueto, Maurizio Soresi, Alberto D'Alcamo, Aurelio Seidita, Beatrice Mantia, Francesca Fayer, Francesco La Blasca, Maria Chiara Garlisi

Risultato della ricerca: Articlepeer review


Background: Lactose intolerance is the most frequent food intolerance, but many subjects with self‐reported milk intolerance (SRMI) are asymptomatic at lactose hydrogen breath test (LHBT). The aim of this study was to evaluate the frequency of lactose intolerance in SRMI patients and their clinical characteristics. Methods: In a retrospective study, the clinical records of 314 SRMI patients (259 females, mean age: 39.1 ± 13.5 years) were reviewed; 102 patients with irritable bowel syndrome (IBS) served as controls. In a prospective study, 42 SRMI patients, negatives at the LHBT, underwent a double‐blind, placebo‐controlled (DBPC) whole cow’s milk challenge. Results: In the retrospective study, only 178 patients (56%) were lactose maldigesters and intolerant at LHBT; 68% of the subjects with SRMI were suffering from IBS; 74% reported dyspepsia (p = 0.0001 vs. IBS controls); and weight loss was recorded in 62 SRMI patients (20%) (p = 0.01 vs. IBS controls). Duodenal histology showed intra‐epithelial lymphocytosis in about 60% of cases. In the prospective study, 36 patients (86%) experienced symptoms during the DBPC cow’s milk challenge, and only 4 patients (9%) reacted to placebo (p = 0.0001). Conclusions: A percentage of SRMI patients were not suffering from lactose intolerance. DBPC revealed that SRMI patients had clinical reactions when exposed to whole cow’s milk.
Lingua originaleEnglish
pagine (da-a)3833-3842
Numero di pagine10
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2900.2916???

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