Which patients with genotype 1 chronic hepatitis C can benefit from prolongedtreatment with the 'accordion' regimen?

Antonio Craxi, E. Jenny Heathcote, Patrick Marcellin

Risultato della ricerca: Articlepeer review

36 Citazioni (Scopus)


The on-treatment virological response to pegylated interferon plus ribavirin therapy is a useful tool in the management of patients with chronic hepatitis C. The time at which hepatitis C virus RNA becomes undetectable by a sensitive PCR assay has a huge impact on the probability of achieving a sustained virological response, particularly in genotype 1 patients, and may be useful in selecting patients for prolonged therapy. Indiscriminate extension of treatment in patients with hepatitis C virus genotype 1 is not beneficial. However, there is a subgroup of patients – the so-called ‘slow responders’ – who benefit from extending treatment from 48 to 72 weeks and can be readily identified after 4–12 weeks of combination therapy. Thus, it is important to distinguish slow responders from null responders. In the TeraVIC-4 study virological relapse rates were significantly lower, and sustained virological response rates were significantly higher, in those treated for 72 weeks with peginterferon alfa-2a (40 kDa) plus ribavirin (45% vs. 32% with 48 weeks, P = 0.014). Patients are best served by quantitative determination of the hepatitis C virus RNA level at weeks 4, 12 and 24. The results of these determinations can then be used to tailor the length of therapy.
Lingua originaleEnglish
pagine (da-a)580-587
Numero di pagine8
RivistaJournal of Hepatology
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

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