TY - JOUR
T1 - What links BRAF to the heart function? New insights from the cardiotoxicity of BRAF inhibitors in cancer treatment
AU - Novo, Giuseppina
AU - Bronte, Giuseppe
AU - Brancatelli, Giuseppe
AU - Russo, Antonio
AU - Novo, Salvatore
AU - Bronte, Fabrizio
AU - Bazan, Viviana
AU - Russo, Antonio
AU - Bronte, Enrico
AU - Bazan, Viviana
AU - Natoli, Clara
AU - Bronte, Giuseppe
AU - Bronte, Enrico
AU - Bavetta, Maria Grazia
PY - 2015
Y1 - 2015
N2 - The RAS-related signalling cascade has a fundamental role in cell. It activates differentiation and survival. It is particularly important one of its molecules, B-RAF. B-RAF has been a central point for research, especially in melanoma. Indeed, it lacked effective therapeutic weapons since the early years of its study. Molecules targeting B-RAF have been developed. Nowadays, two classes of molecules are approved by FDA. Multi-target molecules, such as Sorafenib and Regorafenib, and selective molecules, such as Vemurafenib and Dabrafenib. Many other molecules are still under investigation. Most of them are studied in phase 1 trials. Clinical studies correlate B-RAF inhibitors and QT prolongation. Though this cardiovascular side effect is not common using these drugs, it must be noticed early and recognize its signals. Indeed, Oncologists and Cardiologists should work in cooperation to prevent lethal events, such as fatal arrhythmias or sudden cardiac death. These events could originate from an uncontrolled QT prolongation.
AB - The RAS-related signalling cascade has a fundamental role in cell. It activates differentiation and survival. It is particularly important one of its molecules, B-RAF. B-RAF has been a central point for research, especially in melanoma. Indeed, it lacked effective therapeutic weapons since the early years of its study. Molecules targeting B-RAF have been developed. Nowadays, two classes of molecules are approved by FDA. Multi-target molecules, such as Sorafenib and Regorafenib, and selective molecules, such as Vemurafenib and Dabrafenib. Many other molecules are still under investigation. Most of them are studied in phase 1 trials. Clinical studies correlate B-RAF inhibitors and QT prolongation. Though this cardiovascular side effect is not common using these drugs, it must be noticed early and recognize its signals. Indeed, Oncologists and Cardiologists should work in cooperation to prevent lethal events, such as fatal arrhythmias or sudden cardiac death. These events could originate from an uncontrolled QT prolongation.
UR - http://hdl.handle.net/10447/176830
UR - http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path[]=5853&path[]=13964
M3 - Article
VL - 6
SP - 35589
EP - 35601
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
ER -