What happens to the BRONJpatients when re-classifiedaccording to the novel SICMFSIPMOrecommendations? Our experience

Risultato della ricerca: Otherpeer review


Background. Since 2009, according to the American Association of Oral and Maxillofacial Surgeons staging system(AAOMS-SS), Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ) has been defined by the presence ofbone exposition; in absence of this condition, patients presenting other unspecific clinical and/or radiological signs ofdisease were classified into the “stage 0”. In 2012, the Italian Society of Maxillo-Facial Surgery (SICMF) and the ItalianSociety of Oral Pathology and Medicine (SIPMO) redefined BRONJ, as an adverse drug event, with several clinicalforms (exposed and not-exposed), and updated the staging system, abolishing the stage 0. Aim of this study wasto re-classify BRONJ cases in order to define the most adequate managements accordingly. Method. A retrospective database analysis of BRONJ cases observed at the Sector of Oral Medicine-University ofPalermo from 2005 to 2012 was performed. A total of 93 patients (M: 27; F: 66; mean age ± SD 69 ±7yy), previously classified according 2009 AAOMS-SS (stages 0, 1, 2 and 3), were reclassified according 2012 SICMF-SIPMO staging system (SS-SS) [stage 1 (focal); 2 (diffuse) and 3 complicated)].Results. In our sample, BRONJ AAOMS staging was the following: “stage 0” 16/93 (17.2%); “stage 1” 16/93(17.2%); “stage 2” 48/93 (51.6%) and “stage 3” 13/93 (14%). On the basis of the novel SS-SS, distribution of caseswere: “stage 1” 33/93 (35.5%); “stage 2” 41/93 (44.1%) and “stage 3” 19/93 (20.4%). Of the 16 cases “stage 0”, 6/16(37.5%) has become “stage 1”; 6/16 (37.5%) “stage 2” and 4/16 (25%) “stage 3”, respectively.Conclusion. After the re-classification, a large quote of BRONJ cases, previously underestimated as stage 0, wereproperly diagnosed as diffuse-complicated cases. According to our experience, the updated staging system provide important clinical benefits, such as anticipating BRONJ diagnosis, performing therapies earlier and adequate to the correct staging, in order to increase treatment effectiveness.
Lingua originaleEnglish
Numero di pagine2
Stato di pubblicazionePublished - 2014


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