TY - JOUR
T1 - What are the Cancer Risks in BRCA Carriers Apart from Those Regarding the Breast and the Ovary?
AU - Russo, Antonio
AU - Cucinella, Gaspare
AU - Bazan, Viviana
AU - La Paglia, Laura
AU - Bruno, Leonardo
AU - Di Gaudio, Francesca
AU - Cicero, Giuseppe
AU - Margarese, Naomi
AU - Pantuso, Gianni
AU - Calo', Valentina
AU - Di Piazza, null
AU - Margarese, null
AU - Ricciardi, Giuseppina Rosaria Rita
AU - Guadagna, Francesca Paola
AU - Russo, null
AU - Cicero, null
AU - Guarneri, null
AU - La Paglia, null
AU - Rolfo Cervetto, Christian
AU - Bazan, Viviana
AU - Calò, Valentina
AU - Bruno, null
AU - Russo, Andrea
AU - Di Piazza, Fabiola
AU - Di Piazza, Florinda
AU - Guarneri, Giovanni
PY - 2012
Y1 - 2012
N2 - Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose to familial breast and/or ovarian cancer. The lifetime risk of members of families with genetic predisposition depends on the mutations of susceptibility genes. BRCA1 mutations seem to confer the highest risk of developing neoplastic diseases.Apart from breast and ovarian cancer mutations in BRCA, related pathways are supposed to confer a smaller risk for additional cancers (colon, melanoma, pancreas, lymphoma, prostate, liver). All these tumors have an inherited component not necessarily associated with genetic susceptibility to BRCA genes.To date he main focus of this review has been argued still with difficulty. Just a deeper and complete evaluation of the topic will allow to establish how much is the contribution of BRCA mutations in different types of cancers other than breast and ovary.
AB - Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose to familial breast and/or ovarian cancer. The lifetime risk of members of families with genetic predisposition depends on the mutations of susceptibility genes. BRCA1 mutations seem to confer the highest risk of developing neoplastic diseases.Apart from breast and ovarian cancer mutations in BRCA, related pathways are supposed to confer a smaller risk for additional cancers (colon, melanoma, pancreas, lymphoma, prostate, liver). All these tumors have an inherited component not necessarily associated with genetic susceptibility to BRCA genes.To date he main focus of this review has been argued still with difficulty. Just a deeper and complete evaluation of the topic will allow to establish how much is the contribution of BRCA mutations in different types of cancers other than breast and ovary.
UR - http://hdl.handle.net/10447/77918
M3 - Article
SN - 1573-4048
VL - 8
SP - 65
EP - 71
JO - Current Women's Health Reviews
JF - Current Women's Health Reviews
ER -