Voltammetric determination of platinum in perfusate and blood:preliminary data on pharmacokinetic study of arterial infusion with oxaliplatin

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Abstract

Because Platinum Group Elements have found widespread use in catalytic converters in cars and as chemotherapeuticagent, interest in the development of reliable analytical methods is carried out in order tomonitor these analita in humans to protect the citizen's health.Considering that information on the levels of many trace elements in biological matrices is scarce and formany non-essential elements, baseline levels in the population, and especially in those particularly exposedto the risk are lacking, in this paper we optimize an analytical method for biological matrices, using a voltammetrictechnique to measure the concentration of Pt in blood and perfusate.The amount of Pt recovered from the blood and perfusate samples spiked with analita was observed to bemeanly of 95% with 5–6% of R.S.D. These results indicated that proposed method for the determination ofplatinum in biological materials is accurate and reproducible.The amounts of platinum found in the blood samples of common ranged citizen were similar to quantificationlimit while in the patients the concentration ranged from 1.5 to 360 μg/L, in perfusate ranged from 0.7to 9700 μg/l. The concentrations of Pt of populace and in patients before of infusion are in agreement withthe level measured in the blood of unexposed patients.The proposed analytical method permits to determine the amount of Pt in the perfusate and subsequentlyabsorbed by the target organs in order to determine the dose and timing of treatment and to avoid overdoseswith related undesired effects.
Lingua originaleEnglish
pagine (da-a)72-76
Numero di pagine5
RivistaMicrochemical Journal
Volume100
Stato di pubblicazionePublished - 2012

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Spectroscopy

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