Vitamin K deficiency bleeding leading to a diagnosis of Crohn’s Disease

Luisa Agnello, Marcello Ciaccio, Giulia Bivona, Antonietta Caruso, Chiara Bellia, Mariasanta Napolitano, Bruna Lo Sasso, Lucio Lo Coco, Marcello Ciaccio, Mariasanta Napolitano, Rossella Gnoffo, Felicia Coraci, Filippa Bonura, Silvana Vitale

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We report the case of a 45 year old man who came to Emergency Room of Polyclinic for sudden onset of localized ecchymosis and widespread hematomas. He was subjected to blood count and first level investigations to assess coagulation. Based on the results, second level investigations were performed. Endoscopy of the gastrointestinal tract with histological examination revealed a diagnosis of Crohn's disease. Vitamin K deficiency causes the formation of vitamin K-dependent clotting factors that cannot perform their pro-coagulant action. Consequently, patients present with hemorrhagic manifestations. Clinical and laboratory features observed in this patient show that the deficiency of vitamin K-dependent coagulation factors may reveal a complex clinical condition such as an inflammatory bowel disease.
Lingua originaleEnglish
Numero di pagine4
RivistaAnnals of Clinical and Laboratory Science
Stato di pubblicazionePublished - 2014


All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

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