Abstract

Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo.Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy.Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar.Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents
Lingua originaleEnglish
pagine (da-a)1-37
Numero di pagine37
RivistaPharmaceutical Biology
Volumesi
Stato di pubblicazionePublished - 2015

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Chemoprevention
Vitamin D
Neoplasms
Prostatic Neoplasms
PubMed
Antineoplastic Agents
Colorectal Neoplasms
Databases
Breast Neoplasms
Calcium
Health
Growth
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cita questo

@article{f153e15b6c874772a898c21daab40a35,
title = "Vitamin D in cancer chemoprevention",
abstract = "Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo.Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy.Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar.Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents",
author = "{La Guardia}, Maurizio and Marilena Crescimanno and Marco Giammanco and Tumminello, {Francesca Maria} and Carla Flandina and Stefania Aiello and Gaetano Leto and {Di Majo}, Danila",
year = "2015",
language = "English",
volume = "si",
pages = "1--37",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Vitamin D in cancer chemoprevention

AU - La Guardia, Maurizio

AU - Crescimanno, Marilena

AU - Giammanco, Marco

AU - Tumminello, Francesca Maria

AU - Flandina, Carla

AU - Aiello, Stefania

AU - Leto, Gaetano

AU - Di Majo, Danila

PY - 2015

Y1 - 2015

N2 - Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo.Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy.Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar.Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents

AB - Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo.Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy.Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar.Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents

UR - http://hdl.handle.net/10447/130636

UR - http://dx.doi.org/10.3109/13880209.2014.988274

M3 - Article

VL - si

SP - 1

EP - 37

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

ER -