Visceral Adiposity Index (VAI) Is Predictive of an Altered Adipokine Profile in Patients with Type 2 Diabetes

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Abstract

Aims: Although there is still no clear definition of ‘‘adipose tissue dysfunction’’ or ATD, the identification of a clinical markerof altered fat distribution and function may provide the needed tools for early identification of a condition ofcardiometabolic risk. Our aim was to evaluate the correlations among various anthropometric indices [BMI, WaistCircumference (WC), Hip Circumference (HC), Waist/Hip ratio (WHR), Body Adiposity Index (BAI) and Visceral adiposity Index(VAI)] and several adipocytokines [Visfatin, Resistin, Leptin, Soluble leptin receptors (sOB-R), Adiponectin, Ghrelin, Adipsin,PAI-1, vascular endothelial growth factor (VEGF), Hepatocyte growth factor (HGF) TNF-a, hs-CRP, IL-6, IL-18] in patients withtype 2 diabetes (DM2).Materials and Methods: Ninety-one DM2 patients (age: 65.2566.38 years; 42 men and 49 women) in stable treatment forthe last six months with metformin in monotherapy (1.5–2 g/day) were cross-sectionally studied. Clinical, anthropometric,and metabolic parameters were evaluated. Serum adipocytokine levels were assayed with Luminex based kits.Results: At the Pearson’s correlation, among all the indices investigated, VAI showed a significant correlation with almost alladipocytokines analyzed [Visfatin, Resistin and hsCRP (all p,0.001); Adiponectin, sOb-R, IL-6, IL-18, HGF (all p,0.010);Ghrelin and VEGF (both p,0.05)]. Through a two-step cluster analysis, 55 patients were identified with the most alteredadipocytokine profile (patients with ATD). At a ROC analysis, VAI showed the highest C-statistic [0.767 (95% CI 0.66–0.84)] ofall the indices.Conclusions: Our study suggests that the VAI, among the most common indexes of adiposity assessment, shows the bestcorrelation with the best known adipocytokines and cardiometabolic risk serum markers. Although to date we are still farfrom clearly identifying an ATD, the VAI would be an easy tool for clearly mirroring a condition of cardiometabolic risk, in theabsence of an overt metabolic syndrome.
Lingua originaleEnglish
Numero di pagine0
RivistaPLoS One
Volume9
Stato di pubblicazionePublished - 2014

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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