Although still there is no a clear definition of “adipose tissue dysfunction”, theidentification of clinical and biological markers of altered fat distribution and function mayprovide the needed tools to early identify a condition of cardiometabolic risk. VisceralAdiposity Index (VAI) is a mathematical gender-specific index estimated with the use ofsimple anthropometric [(BMI and Waist circumference (WC)] and biochemical parameters[HDL cholesterol (HDL) and Triglycerides (Tg)], that in recent studies has shown toreflect accurately the degree of visceral adiposity and insulin resistance. However, althoughVAI has been indirectly shown to be a marker of impaired fat distribution and function,until to date there are only few studies in which it was correlated with the main adipokines(leptin and adiponectin). Our aim was to evaluate the correlations among various measuresof fat distribution [VAI, BMI, WC, WHR, visceral adipose tissue volume (VAT ) andsubcutaneous adipose tissue volume (SAT) measured by MR between L2 and L4] and acomplete panel of adipocytokines [Visfatin, Resistin, Leptin, Soluble leptin receptors(sOB-R), Leptin/sOb-R ratio, Adiponectin, Ghrelin, Adipsin, PAI-1, vascular endothelialgrowth factor (VEGF), TNF-alpha,??hs-CRP, IL-6, IL-18, Hepatocyte growth factor(HGF)]?in patients with type 2 diabetes (DM2). Ninety-one DM2 patients (age:65.25±6.38 years; duration of disease: 9.73±5.99 years; 42 men and 49 women) in stabletreatment for the last two months with metformin in monotherapy at 2 g/day were screenedfor the study. In all patients the serum levels of adipocytokines were assayed by Luminexbasedkits. In a subset of 13 patients an assessment of VAT and SAT volume wasperformed through a MR. At the Pearson's correlation, among all the investigated measuresof fat distribution, only VAI showed a significant correlation with almost all analyzedcytokines [visfatin (r=0.331, p=0.001), resistin (r=0.354, p=0.001), leptin (r=0.285,p=0.005), sOb-R (r=-0.214, p=0.041), ghrelin (r=-0.225, p=0.032), adiponectin (r=-0.394,p<0.001), VEGF (r=0.247, p=0.018), TNF-alpha (??r=0.333, ??p=0.001), HGF (r=0.245,p=0.019), IL-18 (r=0.317, p=0.002)]; no significant correlation with PAI-1 and adipsin wasfound. Our study suggests VAI, among the most common indexes of adiposity assessment,is a very useful tool well mirroring “adipose tissue dysfunction” in type 2 diabetes.
|Numero di pagine||1|
|Stato di pubblicazione||Published - 2013|