Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project

Roberto Monastero; null Feliziani; null Caputo; null Ercolani; null Senin; null Mecocci; null Vitale; null Mariani; null Mangialasche; Domenico Vitale

Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project

Roberto Monastero, Feliziani, Caputo, Ercolani, Senin, Mecocci, Vitale, Mariani, Mangialasche, Domenico Vitale

Biomedicina, Neuroscienze e Diagnostica avanzata

Risultato della ricerca: Article › peer review

29 Citazioni (Scopus)

Abstract

AbstractBackground and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment(MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI wereincluded in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a)and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesionswere evaluated.Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, ahigher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI.Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.Conclusion: Our findings suggest that snmMCI may be considered a vascular cognitive disorder.

Lingua originale	English
pagine (da-a)	448-456
Numero di pagine	9
Rivista	Dementia and Geriatric Cognitive Disorders
Volume	24
Stato di pubblicazione	Published - 2007

All Science Journal Classification (ASJC) codes

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

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title = "Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project",

abstract = "AbstractBackground and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment(MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI wereincluded in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a)and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesionswere evaluated.Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, ahigher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI.Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.Conclusion: Our findings suggest that snmMCI may be considered a vascular cognitive disorder.",

author = "Roberto Monastero and Feliziani and Caputo and Ercolani and Senin and Mecocci and Vitale and Mariani and Mangialasche and Domenico Vitale",

year = "2007",

language = "English",

volume = "24",

pages = "448--456",

journal = "Dementia and Geriatric Cognitive Disorders",

issn = "1420-8008",

publisher = "S. Karger AG",

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TY - JOUR

T1 - Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project

AU - Monastero, Roberto

AU - Feliziani, null

AU - Caputo, null

AU - Ercolani, null

AU - Senin, null

AU - Mecocci, null

AU - Vitale, null

AU - Mariani, null

AU - Mangialasche, null

AU - Vitale, Domenico

PY - 2007

Y1 - 2007

N2 - AbstractBackground and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment(MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI wereincluded in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a)and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesionswere evaluated.Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, ahigher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI.Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.Conclusion: Our findings suggest that snmMCI may be considered a vascular cognitive disorder.

AB - AbstractBackground and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment(MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI wereincluded in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a)and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesionswere evaluated.Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, ahigher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI.Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.Conclusion: Our findings suggest that snmMCI may be considered a vascular cognitive disorder.

UR - http://hdl.handle.net/10447/9798

M3 - Article

VL - 24

SP - 448

EP - 456

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

ER -