Use of statins in patients with peripheral artery disease

Egle Corrado, Antonino Mignano, Giuseppe Coppola, Antonino Mignano, Egle Corrado

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)


Atherosclerotic peripheral artery disease (PAD) is a growing health issue that affects more than 200 million individuals worldwide, conferring a high risk of cardiovascular events and death. In spite of its high prevalence, PAD has often been neglected in the past and the heightened cardiovascular risk of patients with PAD has been consistently under-recognized by practitioners. Considering that an integrated approach to reduce cardiovascular events and lower limb complications is necessary in this setting, statins represent the cornerstone of therapy as reported by current American and European guidelines. Literature has extensive data about the importance of lipid-lowering therapy in patients with PAD demonstrating that statins reduce symptoms, cardiovascular events and mortality. Despite data extrapolated from many studies on coronary artery diseases, moderate-dose statin therapy seems to be safe, and the minor risks posed in terms of myopathy-related symptoms are greatly outweighed by benefits. Other lipid-lowering drugs did not show the same results in terms of outcome and they should not be considered as first line therapy in these patients. The role of anti-PCSK9 inhibitors is emerging in the literature but further data are necessary to understand their superiority over statins.
Lingua originaleEnglish
pagine (da-a)257-262
Numero di pagine6
RivistaTrends in Cardiovascular Medicine
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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