The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines ofItalian autistic children up to 8 years of age. The present study aims at replicating these initialfindings in an ethnically distinct sample and at extending them by measuring also the threecomponents of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol.Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33French autism spectrum disorder (ASD) cases compared with 33 sex- and age-matched controls(p50.05). This increase was limited to ASD children aged 8 years (p50.01), and not older(p ¼ 0.17). Urinary levels of p-cresol and p-cresylsulfate were associated with stereotypic,compulsive/repetitive behaviors (p50.05), although not with overall autism severity. Theseresults confirm the elevation of urinary p-cresol in a sizable set of small autistic children andspur interest into biomarker roles for p-cresol and p-cresylsulfate in autism.
|Numero di pagine||8|
|Stato di pubblicazione||Published - 2014|
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
Tripi, G., Sacco, R., Barthelemy, C., Tripi, G., Neri, C., Urbani, A., Gabriele, S., Bonnet-Brihault, F., Cerullo, S., Malvy, J., & Persico, A. M. (2014). Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. Biomarkers.