Uric acid metabolism in pre-hypertension and the metabolic syndrome

Giuseppe Montalto, Manfredi Rizzo, Dragana Nikolic, Esma R. Isenovic, Dimitri P. Mikhailidis, Milica Labudovic-Borovic, Dragana Nikolic, Milan Obradovic, Manfredi Rizzo, Ali A. Rizvi, Manfredi Rizzo

Risultato della ricerca: Article

15 Citazioni (Scopus)

Abstract

In humans uric acid (UA) is the end product of degradation of purines. The handling of UA by the renal system is a complex process which is not fully understood. To date, several urate transporters in the renal proximal tubule have been identified. Among them, urate transporter 1 (URAT1) and a glucose transporter 9 (GLUT9) are considered of greater importance, as potential targets for treatment of hyperuricemia and the potential associated cardio-metabolic risk. Therefore, the recognition of the metabolic pathway of UA and elucidation of occurrence of hyperuricemia may provide important insights about the relationship between UA, pre-hypertension (preHT) and the metabolic syndrome (MetS). We also review the available clinical studies in this field, including experimental studies dealing with the mechanisms of UA transport via different transporters, as well as current treatment options for hyperuricemia in patients with MetS, preHT or cardiovascular risk factors.
Lingua originaleEnglish
pagine (da-a)572-585
Numero di pagine0
RivistaCurrent Vascular Pharmacology
Volume00
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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    Montalto, G., Rizzo, M., Nikolic, D., Isenovic, E. R., Mikhailidis, D. P., Labudovic-Borovic, M., Nikolic, D., Obradovic, M., Rizzo, M., Rizvi, A. A., & Rizzo, M. (2013). Uric acid metabolism in pre-hypertension and the metabolic syndrome. Current Vascular Pharmacology, 00, 572-585.