Upregulated transcription of phenoloxidase genes in the pharynx and endostyle of Ciona intestinalis in response to LPS

Risultato della ricerca: Articlepeer review

13 Citazioni (Scopus)

Abstract

We investigated the role of phenoloxidases (POs) in ascidians inflammatory reaction, a components of acopper-containing protein family involved in invertebrate immune system. In Ciona intestinalis two phenoloxidases(CinPO-1, CinPO-2) have been sequenced. In the present study, real time PCR analysis showedthat both CinPO-1 and CinPO-2 genes were modulated by LPS inoculation suggesting that they are inducibleand highly expressed in the inflamed pharynx. In situ hybridization disclosed CinPO-1 and CinPO-2transcripts in pharynx hemocytes (granulocytes) and, mainly, in unilocular refractile granulocytes (URG)which mainly populated the inflamed tunic matrix. Interestingly, the genes are also upregulated by LPS inthe endostyle (zones 7, 8 and 9) that is considered homolog to the vertebrate thyroid.
Lingua originaleEnglish
pagine (da-a)6-11
Numero di pagine6
RivistaJournal of Invertebrate Pathology
Volume126
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

Fingerprint Entra nei temi di ricerca di 'Upregulated transcription of phenoloxidase genes in the pharynx and endostyle of Ciona intestinalis in response to LPS'. Insieme formano una fingerprint unica.

Cita questo