TY - CHAP
T1 - Update on mechanism and therapeutic implications of spinal cord stimulation and cerebral hemodynamics: A narrative review
AU - Iacopino, Domenico
AU - Zhong, Jun
AU - Peppucci, Elisabetta
AU - Di Bonaventura, Rina
AU - Esposito, Vincenzo
AU - Barbagallo, Giuseppe
AU - Visocchi, Massimiliano
PY - 2017
Y1 - 2017
N2 - Spinal cord stimulation (SCS) is well known for its early role in the management of chronic pain, mainly failed back surgery syndrome (FBSS), spasticity, and bowel and bladder dysfunction. In more recent years, SCS has been proposed for patients suffering from refractory angina or peripheral vasculopathies in order to gain symptom relief, thus indicating some hemodynamic effect on the peripheral circulation. Taking into account this scientific observation, since the late1980s, researchers have started to investigate the potential effect of SCS on cerebral blood flow (CBF) regulation and its possible application in certain pathological settings dealing with vascular pattern dysfunction, such as ischemia, subarachnoid hemorrhage, head trauma, and brain tumors. The aim of this study was to review the scientific literature about SCS and its effect on CBF, evaluating the results both in “physiological” experimental models and clinical studies, as well as in the particular pathological conditions we have mentioned above.
AB - Spinal cord stimulation (SCS) is well known for its early role in the management of chronic pain, mainly failed back surgery syndrome (FBSS), spasticity, and bowel and bladder dysfunction. In more recent years, SCS has been proposed for patients suffering from refractory angina or peripheral vasculopathies in order to gain symptom relief, thus indicating some hemodynamic effect on the peripheral circulation. Taking into account this scientific observation, since the late1980s, researchers have started to investigate the potential effect of SCS on cerebral blood flow (CBF) regulation and its possible application in certain pathological settings dealing with vascular pattern dysfunction, such as ischemia, subarachnoid hemorrhage, head trauma, and brain tumors. The aim of this study was to review the scientific literature about SCS and its effect on CBF, evaluating the results both in “physiological” experimental models and clinical studies, as well as in the particular pathological conditions we have mentioned above.
UR - http://hdl.handle.net/10447/484848
M3 - Chapter
SN - 978-3-319-39545-6; 978-3-319-39546-3
T3 - ACTA NEUROCHIRURGICA. SUPPLEMENTUM
SP - 27
EP - 36
BT - Trends in Reconstructive Neurosurgery : Neurorehabilitation, Restoration and Reconstruction
ER -