Under-prescription of statins in patients with non-alcoholic fatty liver disease

Maurizio Averna, Licia Polimeni, Francesco Violi, Daniele Pastori, Francesco Baratta, Maria Del Ben, Lorenzo Loffredo, Francesco Angelico

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Abstract

Background and Aim Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with high cardiovascular risk. Management of dyslipidaemia plays a pivotal role in the prevention of CV events and statins have proved to be safe in these patients. However, in everyday clinical practice statin prescription is sometimes limited because of the concern of physicians about side-effects. The aim of the study was to investigate if the presence of NAFLD affects the prescription of lipid-lowering treatment in a large series of patients with cardio-metabolic disorders. Methods and Results Cardiovascular risk and LDL-C targets were defined according to ESC/EAS Guidelines in 605 consecutive adult subjects referred for screening of suspected metabolic diseases. Liver steatosis was assessed by ultrasound Hamaguchi criteria. In the whole cohort, 442 patients had indication for cholesterol-lowering treatment. Lack of statin prescription was present in 230 (52.0%) patients. Of these, 77 (33.5%) were very high-risk, 48 (20.8%) high-risk, and 105 (45.6%) moderate risk patients. Only 44% of the NAFLD patients with indication for statin treatment were on therapy. NAFLD patients on statin treatment had significantly lower ALT values as compared to those not on treatment (p < 0.05). Conclusions Our findings show that about 50% of patients with indication to statin treatment do not receive any cholesterol-lowering medication. Statin under-use was particularly high in subjects with NAFLD. Use of statin treatment should be encouraged in the context of NAFLD, as it may improve lipid profile and reduce the cardiovascular risk in this setting.
Lingua originaleEnglish
pagine (da-a)161-167
Numero di pagine7
RivistaNMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume27
Stato di pubblicazionePublished - 2017

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cita questo

Averna, M., Polimeni, L., Violi, F., Pastori, D., Baratta, F., Del Ben, M., Loffredo, L., & Angelico, F. (2017). Under-prescription of statins in patients with non-alcoholic fatty liver disease. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 27, 161-167.