The purpose was to comparehuman brain tissue perfusionin diabetic patients and healthy subjectswith second harmonic imagingultrasound and SonoVue to test thehypothesis that brain tissue perfusiondifferences are present in these twogroups of patients. In a prospectivecase-control study, second harmonicexaminations performed in 20 patientswith type II diabetes mellitusand in 20 matched control patientswere compared. After administrationof 2.5 ml of SonoVue, 60 time-triggeredimages were recorded. Timeintensitycurves, including peak intensityand positive gradient normalizedto the middle cerebral artery,were calculated to quantify ultrasoundintensity in a region of interest.The Mann-Whitney U-test wasused to reveal any differences betweenhealthy and diabetic subjects.Mean peak intensity was 0.64±0.1 Auin healthy subjects and 0.53±0.09 Auin diabetic patients. Mean positivegradient was 0.04±0.007 Au/s inhealthy subjects and 0.04±0.008 Au/sin diabetic patients. Peak intensityand positive gradient were significantlylower in diabetic patients thanin healthy subjects (P<0.05). Ultrasoundexamination with second harmonicimaging and SonoVue administrationis able to detect clinicallysilent, reduced cerebral perfusion intype II diabetic patients. Diabetic patientshave reduced cerebral perfusionin comparison to healthy subjects.
|Numero di pagine||6|
|Stato di pubblicazione||Published - 2005|
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging