Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease

Carmela Rita Balistreri, Calogera Pisano, Federica Campolo, Susanna Dolci, Valeriana Cesarini, Eugenia Guida, Clara Crescioli, Angela Di Baldassarre, Emmanuele A. Jannini, Giovanni Ruvolo, Ermanno Guida

Risultato della ricerca: Articlepeer review

Abstract

Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. The overall goal is to underscore the importance of PDE5 expression and activity in this cell type in the context of the organs where its function has been extensively studied.
Lingua originaleEnglish
pagine (da-a)111311-
Numero di pagine8
RivistaMechanisms of Ageing and Development
Volume190
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Ageing
  • Developmental Biology

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