Tumor diagnosis preceding Parkinson's disease: a case-control study.

Paolo Ragonese, Marco D'Amelio, Giovanni Savettieri, Giuseppe Salemi, Antonio Epifanio, Letterio Morgante, Graziella Callari

Risultato della ricerca: Articlepeer review

27 Citazioni (Scopus)


Lower cancer risk in Parkinson’s disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case– control study to estimate the association oftumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant,or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors.We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI],0.2– 0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% CI, 0.1– 0.7). PD patients had a decreased risk both formalignant (adjusted OR, 0.6; 95% CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1– 0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3;95% CI, 0.1– 0.9) and non–endocrine-related tumors (adjusted OR, 0.4; 95% CI, 0.1– 0.9). Our study confirms the inverse association between PD and neoplasms reported in previousepidemiologic studies.
Lingua originaleEnglish
pagine (da-a)807-811
Numero di pagine5
RivistaMovement Disorders
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2800.2808???
  • ???subjectarea.asjc.2700.2728???


Entra nei temi di ricerca di 'Tumor diagnosis preceding Parkinson's disease: a case-control study.'. Insieme formano una fingerprint unica.

Cita questo