Abstract
Lower cancer risk in Parkinson’s disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case– control study to estimate the association oftumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant,or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors.We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI],0.2– 0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% CI, 0.1– 0.7). PD patients had a decreased risk both formalignant (adjusted OR, 0.6; 95% CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1– 0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3;95% CI, 0.1– 0.9) and non–endocrine-related tumors (adjusted OR, 0.4; 95% CI, 0.1– 0.9). Our study confirms the inverse association between PD and neoplasms reported in previousepidemiologic studies.
Lingua originale | English |
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pagine (da-a) | 807-811 |
Numero di pagine | 5 |
Rivista | Movement Disorders |
Volume | 19(7) |
Stato di pubblicazione | Published - 2004 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.2800.2808???
- ???subjectarea.asjc.2700.2728???