Tumor diagnosis preceding Parkinson's disease: a case-control study.

Morgante, L.; Epifanio, A.

Risultato della ricerca: Article

24 Citazioni (Scopus)

Abstract

Lower cancer risk in Parkinson’s disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case– control study to estimate the association of tumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant, or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors. We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI], 0.2– 0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% CI, 0.1– 0.7). PD patients had a decreased risk both for malignant (adjusted OR, 0.6; 95% CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1– 0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3; 95% CI, 0.1– 0.9) and non–endocrine-related tumors (adjusted OR, 0.4; 95% CI, 0.1– 0.9). Our study confirms the inverse association between PD and neoplasms reported in previous epidemiologic studies.
Lingua originaleEnglish
pagine (da-a)807-811
Numero di pagine5
RivistaMovement Disorders
Volume19(7)
Stato di pubblicazionePublished - 2004

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Parkinson Disease
Case-Control Studies
Odds Ratio
Confidence Intervals
Neoplasms
Death Certificates
Logistic Models
Population

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neuroscience(all)

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Tumor diagnosis preceding Parkinson's disease: a case-control study. / Morgante, L.; Epifanio, A.

In: Movement Disorders, Vol. 19(7), 2004, pag. 807-811.

Risultato della ricerca: Article

Morgante, L.; Epifanio, A. 2004, 'Tumor diagnosis preceding Parkinson's disease: a case-control study.', Movement Disorders, vol. 19(7), pagg. 807-811.
Morgante, L.; Epifanio, A. / Tumor diagnosis preceding Parkinson's disease: a case-control study. In: Movement Disorders. 2004 ; Vol. 19(7). pagg. 807-811.
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title = "Tumor diagnosis preceding Parkinson's disease: a case-control study.",
abstract = "Lower cancer risk in Parkinson’s disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case– control study to estimate the association of tumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant, or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors. We included 222 PD patients. Frequency of cancer was 6.8{\%} for cases, 12.6{\%} for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95{\%} confidence interval [CI], 0.2– 0.7). Risk was reduced only for women (adjusted OR, 0.3; 95{\%} CI, 0.1– 0.7). PD patients had a decreased risk both for malignant (adjusted OR, 0.6; 95{\%} CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95{\%} CI, 0.1– 0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3; 95{\%} CI, 0.1– 0.9) and non–endocrine-related tumors (adjusted OR, 0.4; 95{\%} CI, 0.1– 0.9). Our study confirms the inverse association between PD and neoplasms reported in previous epidemiologic studies.",
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T1 - Tumor diagnosis preceding Parkinson's disease: a case-control study.

AU - Morgante, L.; Epifanio, A.

AU - Savettieri, Giovanni

AU - Salemi, Giuseppe

AU - D'Amelio, Marco

AU - Ragonese, Paolo

AU - Callari, Graziella

PY - 2004

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N2 - Lower cancer risk in Parkinson’s disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case– control study to estimate the association of tumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant, or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors. We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI], 0.2– 0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% CI, 0.1– 0.7). PD patients had a decreased risk both for malignant (adjusted OR, 0.6; 95% CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1– 0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3; 95% CI, 0.1– 0.9) and non–endocrine-related tumors (adjusted OR, 0.4; 95% CI, 0.1– 0.9). Our study confirms the inverse association between PD and neoplasms reported in previous epidemiologic studies.

AB - Lower cancer risk in Parkinson’s disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case– control study to estimate the association of tumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant, or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors. We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI], 0.2– 0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% CI, 0.1– 0.7). PD patients had a decreased risk both for malignant (adjusted OR, 0.6; 95% CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1– 0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3; 95% CI, 0.1– 0.9) and non–endocrine-related tumors (adjusted OR, 0.4; 95% CI, 0.1– 0.9). Our study confirms the inverse association between PD and neoplasms reported in previous epidemiologic studies.

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