Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 807-811 |
| Numero di pagine | 5 |
| Rivista | Movement Disorders |
| Volume | 19(7) |
| Stato di pubblicazione | Published - 2004 |
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All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Neuroscience(all)
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Tumor diagnosis preceding Parkinson's disease: a case-control study. / Morgante, L.; Epifanio, A.
In: Movement Disorders, Vol. 19(7), 2004, pag. 807-811.Risultato della ricerca: Article
}
TY - JOUR
T1 - Tumor diagnosis preceding Parkinson's disease: a case-control study.
AU - Morgante, L.; Epifanio, A.
AU - Savettieri, Giovanni
AU - Salemi, Giuseppe
AU - D'Amelio, Marco
AU - Ragonese, Paolo
AU - Callari, Graziella
PY - 2004
Y1 - 2004
N2 - Lower cancer risk in Parkinson’s disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case– control study to estimate the association of tumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant, or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors. We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI], 0.2– 0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% CI, 0.1– 0.7). PD patients had a decreased risk both for malignant (adjusted OR, 0.6; 95% CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1– 0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3; 95% CI, 0.1– 0.9) and non–endocrine-related tumors (adjusted OR, 0.4; 95% CI, 0.1– 0.9). Our study confirms the inverse association between PD and neoplasms reported in previous epidemiologic studies.
AB - Lower cancer risk in Parkinson’s disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case– control study to estimate the association of tumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant, or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors. We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI], 0.2– 0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% CI, 0.1– 0.7). PD patients had a decreased risk both for malignant (adjusted OR, 0.6; 95% CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1– 0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3; 95% CI, 0.1– 0.9) and non–endocrine-related tumors (adjusted OR, 0.4; 95% CI, 0.1– 0.9). Our study confirms the inverse association between PD and neoplasms reported in previous epidemiologic studies.
UR - http://hdl.handle.net/10447/16257
M3 - Article
VL - 19(7)
SP - 807
EP - 811
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
ER -