Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium

Giovanni Savettieri; Giuseppe Salemi; Italia Di Liegro; Donatella Ferraro; Alessandro Cestelli; Donatella Ferraro; Roberto Gristina; Daniele Castiglia; Italia Di Liegro; Alessandro Cestelli

Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium

Giovanni Savettieri, Giuseppe Salemi, Italia Di Liegro, Donatella Ferraro, Alessandro Cestelli, Donatella Ferraro, Roberto Gristina, Daniele Castiglia, Italia Di Liegro, Alessandro Cestelli

Risultato della ricerca: Article › peer review

18 Citazioni (Scopus)

Abstract

Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright © 1987, Wiley Blackwell. All rights reserved

Lingua originale	English
pagine (da-a)	1053-1059
Numero di pagine	7
Rivista	Journal of Neurochemistry
Volume	48
Stato di pubblicazione	Published - 1987

All Science Journal Classification (ASJC) codes

Biochemistry
Cellular and Molecular Neuroscience

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Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium. / Savettieri, Giovanni ; Salemi, Giuseppe ; Di Liegro, Italia ; Ferraro, Donatella; Cestelli, Alessandro; Ferraro, Donatella; Gristina, Roberto; Castiglia, Daniele; Di Liegro, Italia; Cestelli, Alessandro.

In: Journal of Neurochemistry, Vol. 48, 1987, pag. 1053-1059.

Risultato della ricerca: Article › peer review

Savettieri, Giovanni ; Salemi, Giuseppe ; Di Liegro, Italia ; Ferraro, Donatella ; Cestelli, Alessandro ; Ferraro, Donatella ; Gristina, Roberto ; Castiglia, Daniele ; Di Liegro, Italia ; Cestelli, Alessandro. / Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium. In: Journal of Neurochemistry. 1987 ; Vol. 48. pagg. 1053-1059.

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title = "Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium",

abstract = "Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright {\textcopyright} 1987, Wiley Blackwell. All rights reserved",

keywords = "Biochemistry, Cellular and Molecular Neuroscience, Chemically denned medium), Chromatin structure, Neuronal terminal differentiation, Triiodothyronine, Biochemistry, Cellular and Molecular Neuroscience, Chemically denned medium), Chromatin structure, Neuronal terminal differentiation, Triiodothyronine",

author = "Giovanni Savettieri and Giuseppe Salemi and {Di Liegro}, Italia and Donatella Ferraro and Alessandro Cestelli and Donatella Ferraro and Roberto Gristina and Daniele Castiglia and {Di Liegro}, Italia and Alessandro Cestelli",

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T1 - Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium

AU - Savettieri, Giovanni

AU - Salemi, Giuseppe

AU - Di Liegro, Italia

AU - Ferraro, Donatella

AU - Cestelli, Alessandro

AU - Ferraro, Donatella

AU - Gristina, Roberto

AU - Castiglia, Daniele

AU - Di Liegro, Italia

AU - Cestelli, Alessandro

PY - 1987

Y1 - 1987

N2 - Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright © 1987, Wiley Blackwell. All rights reserved

AB - Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright © 1987, Wiley Blackwell. All rights reserved

KW - Biochemistry

KW - Cellular and Molecular Neuroscience

KW - Chemically denned medium)

KW - Chromatin structure

KW - Neuronal terminal differentiation

KW - Triiodothyronine

KW - Biochemistry

KW - Cellular and Molecular Neuroscience

KW - Chemically denned medium)

KW - Chromatin structure

KW - Neuronal terminal differentiation

KW - Triiodothyronine

UR - http://hdl.handle.net/10447/207494

M3 - Article

VL - 48

SP - 1053

EP - 1059

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

ER -