TY - JOUR
T1 - Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium
AU - Savettieri, Giovanni
AU - Salemi, Giuseppe
AU - Di Liegro, Italia
AU - Ferraro, Donatella
AU - Cestelli, Alessandro
AU - Ferraro, Donatella
AU - Gristina, Roberto
AU - Castiglia, Daniele
AU - Di Liegro, Italia
AU - Cestelli, Alessandro
PY - 1987
Y1 - 1987
N2 - Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright © 1987, Wiley Blackwell. All rights reserved
AB - Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright © 1987, Wiley Blackwell. All rights reserved
KW - Biochemistry
KW - Cellular and Molecular Neuroscience
KW - Chemically denned medium)
KW - Chromatin structure
KW - Neuronal terminal differentiation
KW - Triiodothyronine
KW - Biochemistry
KW - Cellular and Molecular Neuroscience
KW - Chemically denned medium)
KW - Chromatin structure
KW - Neuronal terminal differentiation
KW - Triiodothyronine
UR - http://hdl.handle.net/10447/207494
M3 - Article
VL - 48
SP - 1053
EP - 1059
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
ER -