Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy

Francesco Vitale, Manuel Zorzi, Emanuela Bovo, Magoni, Coviello, Tisano, Stefano Ferretti, Minerba, Candela, Chiaranda, Stefano Rosso, Anna Melcarne, Anna Clara Fanetti, Usala, Rosanna Cusimano, Ardizzone, Carlotta Buzzoni, Luca Cavalieri D’Oro, Stefano Guzzinati, Antonella Sutera SardoGiorno, Anna Luisa Caiazzo, Bianca Caruso, Fusco, Brustolin, Lorenza Boschetti, Ferretti, Silvia Francisci, Vitale, Chiaranda, Castelli, La Greca, D‘Argenzio, D‘Orsi, Pisani, Silvia Iacovacci, Palma, Cania, Adele Caldarella, Ricci, Fusco, Falcini, Chiaranda, Rosaria Cesaraccio, Lucia Mangone, Silvano Piffer, Salvatore Sciacca, Giovanna Tagliabue, Antonella Puppo, Giuseppe Sampietro, Galasso, Massimo Rugge, Luigino Dal Maso, Rosario Tumino, Diego Serraino, Guido Mazzoleni, Antonio Russo, Michiara, Francesca Bovo, Marco Buzzoni, Mariagrazia Tumino, Marina Usala

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

Objective: To evaluate the trends of colorectal cancer (CRC) incidence and mortality rates from 2003 to 2014 in Italy by age groups and regions. Methods: We used the data of 48 cancer registries from 17 Italian regions to estimate standardized incidence and mortality rates overall and by sex, age groups (<50, 50–69, 70+ years), and geographic area (northwest, northeast, center, south, and islands). Time trends were expressed as annual percent change in rates (APC) with 95% confidence intervals (95% CI). Results: Incidence rates decreased from 104.3 (2003) to 89.9 × 100,000 (2014) in men and from 64.3 to 58.4 × 100,000 in women. Among men, incidence decreased during 2007–2010 (APC −4.0, 95% CI −6.0 to −1.9) and 2010–2014 (APC −0.7, 95% CI −1.4 to 0.0), while in women it linearly decreased during the whole period (APC −1.1, 95% CI −1.4 to −0.8). Mortality rates showed a linear reduction both in men (APC −0.7, 95% CI −1.0 to −0.3) and women (APC −0.9, 95% CI −1.2 to −0.6) and decreased respectively from 41.1 to 39.2 × 100,000 and from 24.6 to 23.1 × 100,000. In the 50- to 69-year-old range (screening target age), incidence showed a prescreening increase, followed by a peak after screening started, and a decline thereafter. Incidence and mortality rates significantly decreased in all areas but in the south and islands, where incidence increased and mortality remained stable. Conclusions: A renewed commitment by all regional health systems to invest in primary (i.e., lifestyle) and secondary (i.e., screening programs) prevention is of utmost importance.
Lingua originaleEnglish
pagine (da-a)417-426
Numero di pagine10
RivistaTumori
Volume105
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Vitale, F., Zorzi, M., Bovo, E., Magoni, Coviello, Tisano, Ferretti, S., Minerba, Candela, Chiaranda, Rosso, S., Melcarne, A., Fanetti, A. C., Usala, Cusimano, R., Ardizzone, Buzzoni, C., Cavalieri D’Oro, L., Guzzinati, S., ... Usala, M. (2019). Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy. Tumori, 105, 417-426.