Transmission of drug-resistant HIV type 1 strains in HAART-naive patients: a 5-year retrospective study in Sicily, Italy.

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Abstract

The transmission of drug-resistant HIV-1 strains might compromise the efficacy of current first-line antiretroviral(ARV) regimens. Between 2004 and 2008, HIV-1 reverse transcriptase (RT) and protease (PR) genes of 108 ARVnaiveSicilian patients were amplified and sequenced to describe the prevalence of ARV resistance mutationsamong HAART-naive HIV-1-infected individuals. The frequency of transmitted drug resistance mutations(DRAMs) was determined by using genotypic interpretation algorithms. The proportion of HAART-naive HIV-1-infected patients in Sicily increased from 18.4% to 23.5% during 2004–2008. Among naive patients, the overallprevalence of DRAMs was 15.7% [17/108; 95% CI: 9.4–24.0]. DRAMs to nonnucleoside reverse transcriptaseinhibitors (nNRTI) were detected most frequently [11/108 (10.2%)], of which K103N was the most prevalent(4.6%), whereas the prevalence of DRAMs was lowest for protease inhibitors (PI) [3/108 (2.8%)]. Drug resistancesubstitutions associated with two or three drug classes were rarely observed. The prevalence of HIV-1 DRAMsin Sicily was relatively higher than that observed in Italy and other European geographic areas and much higherthan in resource-limited countries. However, the possible clinical role played by DRAMs in HAART-naive HIV-1-infected individuals will require further assessment.
Lingua originaleEnglish
pagine (da-a)961-965
Numero di pagine5
RivistaAIDS Research and Human Retroviruses
Volume26
Stato di pubblicazionePublished - 2010

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

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