Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis;survival rate and prognostic factors

Mario Cottone, Franco Valenza, Antonio Buccellato, Sonia Di Piazza

Risultato della ricerca: Article

17 Citazioni (Scopus)

Abstract

Background: The role of prognostic variables in the treatment of hepatocellular carcinoma (HCC) bytransarterial chemoembolisation (TACE) is controversial.Aims: To evaluate the survival of patients with HCC on cirrhosis treated with TACE and to analyse theprognostic factors affecting survival.Methods: From 1996 to 2006, 580 consecutive patients with HCC in cirrhosis were observed. Of these 194patients underwent TACE. The primary end-point was survival. Independent predictors of survival wereidentified using the Cox model.Results: The cumulative 1-year, 3-year, and 5-year survival rates were 96%, 60%, and 41%, respectively.The multivariate analysis showed significant reduction of survival among patients with serum bilirubinvalues >2 mg/dl compared to patients with values <2 mg/dl (Hazard ratio 3.84; CI 95% 1.70–8.66; pvalue= 0.001). Multivariate analysis performed in the group of patients treated with TACE alone showedthat elevated serum bilirubin (Hazard ratio 2.96; CI 95% 1.20–7.3; p-value 0.02) and incomplete tumourresponse (Hazard ratio 2.88; CI 95% 1.18–7.05; p-value 0.02) are correlated with a worse outcome.Conclusions: TACE was well tolerated and overall survival rate was 41% after 5 years. Complete tumourresponse and serum bilirubin <2 mg/dl were identified as predictors of survival.
Lingua originaleEnglish
pagine (da-a)515-519
Numero di pagine5
RivistaDigestive and Liver Disease
Volume42
Stato di pubblicazionePublished - 2010

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Hepatocellular Carcinoma
Fibrosis
Survival Rate
Survival
Bilirubin
Multivariate Analysis
Serum
Proportional Hazards Models
Statistical Factor Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis;survival rate and prognostic factors. / Cottone, Mario; Valenza, Franco; Buccellato, Antonio; Di Piazza, Sonia.

In: Digestive and Liver Disease, Vol. 42, 2010, pag. 515-519.

Risultato della ricerca: Article

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title = "Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis;survival rate and prognostic factors",
abstract = "Background: The role of prognostic variables in the treatment of hepatocellular carcinoma (HCC) bytransarterial chemoembolisation (TACE) is controversial.Aims: To evaluate the survival of patients with HCC on cirrhosis treated with TACE and to analyse theprognostic factors affecting survival.Methods: From 1996 to 2006, 580 consecutive patients with HCC in cirrhosis were observed. Of these 194patients underwent TACE. The primary end-point was survival. Independent predictors of survival wereidentified using the Cox model.Results: The cumulative 1-year, 3-year, and 5-year survival rates were 96{\%}, 60{\%}, and 41{\%}, respectively.The multivariate analysis showed significant reduction of survival among patients with serum bilirubinvalues >2 mg/dl compared to patients with values <2 mg/dl (Hazard ratio 3.84; CI 95{\%} 1.70–8.66; pvalue= 0.001). Multivariate analysis performed in the group of patients treated with TACE alone showedthat elevated serum bilirubin (Hazard ratio 2.96; CI 95{\%} 1.20–7.3; p-value 0.02) and incomplete tumourresponse (Hazard ratio 2.88; CI 95{\%} 1.18–7.05; p-value 0.02) are correlated with a worse outcome.Conclusions: TACE was well tolerated and overall survival rate was 41{\%} after 5 years. Complete tumourresponse and serum bilirubin <2 mg/dl were identified as predictors of survival.",
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TY - JOUR

T1 - Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis;survival rate and prognostic factors

AU - Cottone, Mario

AU - Valenza, Franco

AU - Buccellato, Antonio

AU - Di Piazza, Sonia

PY - 2010

Y1 - 2010

N2 - Background: The role of prognostic variables in the treatment of hepatocellular carcinoma (HCC) bytransarterial chemoembolisation (TACE) is controversial.Aims: To evaluate the survival of patients with HCC on cirrhosis treated with TACE and to analyse theprognostic factors affecting survival.Methods: From 1996 to 2006, 580 consecutive patients with HCC in cirrhosis were observed. Of these 194patients underwent TACE. The primary end-point was survival. Independent predictors of survival wereidentified using the Cox model.Results: The cumulative 1-year, 3-year, and 5-year survival rates were 96%, 60%, and 41%, respectively.The multivariate analysis showed significant reduction of survival among patients with serum bilirubinvalues >2 mg/dl compared to patients with values <2 mg/dl (Hazard ratio 3.84; CI 95% 1.70–8.66; pvalue= 0.001). Multivariate analysis performed in the group of patients treated with TACE alone showedthat elevated serum bilirubin (Hazard ratio 2.96; CI 95% 1.20–7.3; p-value 0.02) and incomplete tumourresponse (Hazard ratio 2.88; CI 95% 1.18–7.05; p-value 0.02) are correlated with a worse outcome.Conclusions: TACE was well tolerated and overall survival rate was 41% after 5 years. Complete tumourresponse and serum bilirubin <2 mg/dl were identified as predictors of survival.

AB - Background: The role of prognostic variables in the treatment of hepatocellular carcinoma (HCC) bytransarterial chemoembolisation (TACE) is controversial.Aims: To evaluate the survival of patients with HCC on cirrhosis treated with TACE and to analyse theprognostic factors affecting survival.Methods: From 1996 to 2006, 580 consecutive patients with HCC in cirrhosis were observed. Of these 194patients underwent TACE. The primary end-point was survival. Independent predictors of survival wereidentified using the Cox model.Results: The cumulative 1-year, 3-year, and 5-year survival rates were 96%, 60%, and 41%, respectively.The multivariate analysis showed significant reduction of survival among patients with serum bilirubinvalues >2 mg/dl compared to patients with values <2 mg/dl (Hazard ratio 3.84; CI 95% 1.70–8.66; pvalue= 0.001). Multivariate analysis performed in the group of patients treated with TACE alone showedthat elevated serum bilirubin (Hazard ratio 2.96; CI 95% 1.20–7.3; p-value 0.02) and incomplete tumourresponse (Hazard ratio 2.88; CI 95% 1.18–7.05; p-value 0.02) are correlated with a worse outcome.Conclusions: TACE was well tolerated and overall survival rate was 41% after 5 years. Complete tumourresponse and serum bilirubin <2 mg/dl were identified as predictors of survival.

KW - hepatocellular carcinoma

KW - transcatheter chemioembiolization

UR - http://hdl.handle.net/10447/52952

M3 - Article

VL - 42

SP - 515

EP - 519

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

ER -