Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 515-519 |
| Numero di pagine | 5 |
| Rivista | Digestive and Liver Disease |
| Volume | 42 |
| Stato di pubblicazione | Published - 2010 |
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All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology
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Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis;survival rate and prognostic factors. / Cottone, Mario; Valenza, Franco; Buccellato, Antonio; Di Piazza, Sonia.
In: Digestive and Liver Disease, Vol. 42, 2010, pag. 515-519.Risultato della ricerca: Article
}
TY - JOUR
T1 - Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis;survival rate and prognostic factors
AU - Cottone, Mario
AU - Valenza, Franco
AU - Buccellato, Antonio
AU - Di Piazza, Sonia
PY - 2010
Y1 - 2010
N2 - Background: The role of prognostic variables in the treatment of hepatocellular carcinoma (HCC) bytransarterial chemoembolisation (TACE) is controversial.Aims: To evaluate the survival of patients with HCC on cirrhosis treated with TACE and to analyse theprognostic factors affecting survival.Methods: From 1996 to 2006, 580 consecutive patients with HCC in cirrhosis were observed. Of these 194patients underwent TACE. The primary end-point was survival. Independent predictors of survival wereidentified using the Cox model.Results: The cumulative 1-year, 3-year, and 5-year survival rates were 96%, 60%, and 41%, respectively.The multivariate analysis showed significant reduction of survival among patients with serum bilirubinvalues >2 mg/dl compared to patients with values <2 mg/dl (Hazard ratio 3.84; CI 95% 1.70–8.66; pvalue= 0.001). Multivariate analysis performed in the group of patients treated with TACE alone showedthat elevated serum bilirubin (Hazard ratio 2.96; CI 95% 1.20–7.3; p-value 0.02) and incomplete tumourresponse (Hazard ratio 2.88; CI 95% 1.18–7.05; p-value 0.02) are correlated with a worse outcome.Conclusions: TACE was well tolerated and overall survival rate was 41% after 5 years. Complete tumourresponse and serum bilirubin <2 mg/dl were identified as predictors of survival.
AB - Background: The role of prognostic variables in the treatment of hepatocellular carcinoma (HCC) bytransarterial chemoembolisation (TACE) is controversial.Aims: To evaluate the survival of patients with HCC on cirrhosis treated with TACE and to analyse theprognostic factors affecting survival.Methods: From 1996 to 2006, 580 consecutive patients with HCC in cirrhosis were observed. Of these 194patients underwent TACE. The primary end-point was survival. Independent predictors of survival wereidentified using the Cox model.Results: The cumulative 1-year, 3-year, and 5-year survival rates were 96%, 60%, and 41%, respectively.The multivariate analysis showed significant reduction of survival among patients with serum bilirubinvalues >2 mg/dl compared to patients with values <2 mg/dl (Hazard ratio 3.84; CI 95% 1.70–8.66; pvalue= 0.001). Multivariate analysis performed in the group of patients treated with TACE alone showedthat elevated serum bilirubin (Hazard ratio 2.96; CI 95% 1.20–7.3; p-value 0.02) and incomplete tumourresponse (Hazard ratio 2.88; CI 95% 1.18–7.05; p-value 0.02) are correlated with a worse outcome.Conclusions: TACE was well tolerated and overall survival rate was 41% after 5 years. Complete tumourresponse and serum bilirubin <2 mg/dl were identified as predictors of survival.
KW - hepatocellular carcinoma
KW - transcatheter chemioembiolization
UR - http://hdl.handle.net/10447/52952
M3 - Article
VL - 42
SP - 515
EP - 519
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
ER -