Transcatheter arterial chemoembolization for hepatocellular carcinoma in cirrhosis;survival rate and prognostic factors

Mario Cottone, Mario Cottone, Lorenza Scala, Mirko Olivo, Franco Valenza, Salvatore Madonia, Giorgio Fusco, Antonio Buccellato, Sonia Di Piazza, Roberto Virdone, Ciro Marrone, Elio Sciarrino, Ambrogio Orlando

Risultato della ricerca: Articlepeer review

17 Citazioni (Scopus)

Abstract

Background: The role of prognostic variables in the treatment of hepatocellular carcinoma (HCC) bytransarterial chemoembolisation (TACE) is controversial.Aims: To evaluate the survival of patients with HCC on cirrhosis treated with TACE and to analyse theprognostic factors affecting survival.Methods: From 1996 to 2006, 580 consecutive patients with HCC in cirrhosis were observed. Of these 194patients underwent TACE. The primary end-point was survival. Independent predictors of survival wereidentified using the Cox model.Results: The cumulative 1-year, 3-year, and 5-year survival rates were 96%, 60%, and 41%, respectively.The multivariate analysis showed significant reduction of survival among patients with serum bilirubinvalues >2 mg/dl compared to patients with values <2 mg/dl (Hazard ratio 3.84; CI 95% 1.70–8.66; pvalue= 0.001). Multivariate analysis performed in the group of patients treated with TACE alone showedthat elevated serum bilirubin (Hazard ratio 2.96; CI 95% 1.20–7.3; p-value 0.02) and incomplete tumourresponse (Hazard ratio 2.88; CI 95% 1.18–7.05; p-value 0.02) are correlated with a worse outcome.Conclusions: TACE was well tolerated and overall survival rate was 41% after 5 years. Complete tumourresponse and serum bilirubin <2 mg/dl were identified as predictors of survival.
Lingua originaleEnglish
pagine (da-a)515-519
Numero di pagine5
RivistaDigestive and Liver Disease
Volume42
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2715???

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