Training Effects on Laboratory Parameters Are Independent of Genetic Polymorphisms of IL-10 and TNF-alpha (TNF-α)

Background: It is well known that exercise has beneficial effects on health.Although intense exercise is experienced by the body as a condition of stress, a welldesigned training has long term beneficial effects on the organism of an athlete. Lessis known about the effects that the genetic background might have on trainingadaptation and on the consequent modification of laboratory parameters. Methods: In our study we evaluated the blood chemistry parameters of a group of 41 athletescompared with a group of 45 amateur athletes, to assess whether the training haseffects on their variation. In addition we typed our subjects for polymorphisms 308A/G of the tumor necrosis factor-α (TNF-α) and 1082 A/G of Interleukin-10 (IL10).Results: After statistical analysis, performed with Mann-Whitney Test, we observeda statistically significant (p value< 0,05) increase of basophils, eosinophils,monocytes, and total bilirubin and decreased levels of neutrophils, glucose,electrolytes and AST in professionals compared to amateurs. These parameterswere not modified by the genetic background. Actually the training modificationobserved were independent of the presence of pro-inflammatory (carrier allele A of1082 A/G of IL10) or anti-inflammatory alleles (subjects A negative for 308 A/G ofTNFα). Conclusions: The genetic polymorphisms analyzed do not influencechanges in laboratory parameters values induced by professional training.