Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

Filippa Lo Cascio, Antonio Palumbo Piccionello, Fabio Bucchieri, Andrea Pace, Nicha Puangmalai, Filippa Lo Cascio, Anna Ellsworth, Rakez Kayed

Risultato della ricerca: Articlepeer review

8 Citazioni (Scopus)

Abstract

The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies. Recently, it has been demonstrated that the soluble and hydrophobic tau oligomers are highly toxic in vitro due to their capacity towards seeding tau misfolding, thereby propagating the tau pathology seen across different neurodegenerative diseases. Modulating the aggregation state of tau oligomers through the use of small molecules could be a useful therapeutic strategy to target their toxicity, regardless of other factors involved in their formation. In this study, we screened and tested a small library of newly synthesized curcumin derivatives against preformed recombinant tau oligomers. Our results show that the curcumin derivatives affect and modulate the tau oligomer aggregation pathways, converting to a more aggregated non-toxic state as assessed in the human neuroblastoma SH-SY5Y cell line and primary cortical neuron cultures. These results provide insight into tau aggregation and may become a basis for the discovery of new therapeutic agents, as well as advance the diagnostic field for the detection of toxic tau oligomers.
Lingua originaleEnglish
Numero di pagine16
RivistaScientific Reports
Volume9
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Entra nei temi di ricerca di 'Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives'. Insieme formano una fingerprint unica.

Cita questo