TOPICAL CAPSAICIN APPLICATION AND AXON REFLEX VASODILATATION OF THE TONGUE: NEUROGENIC INVOLVEMENT IN THE BURNING MOUTH SYNDROME

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Abstract

Background. The neurogenic inflammation depends on the neuromodulator release by peripheral nervous terminations. A series of different studies proved the existence of a neurogenic phlogosis (NP) in different body sites.Only experiences on rat managed to induce NP at the oral mucosa level. Objectives. Inducing NP at the human mucosa level. Material and Methods. Two groups of patients (group A: M/F: 8/7; mean: 41.14 ± 12.4; range: 24–60; group B:M/F: 8/7; mean: 41.21 ± 12.39; range: 23–60) were examined in authors’ laboratory. The NP was experimentally induced at the lower lip mucosa level after topically applying capsaicin. The vascular consequences were observed through computer videocapillaroscopy techniques (Videocap 100). The lip mucosa of the group A patients was observed in three different time periods: before capsaicin application (t0), after one minute (t1), and after 45 minutes (t2) from capsaicin application. The lip mucosa of the group B patients was observed in four different time periods: before capsaicin application (t0), after local anaesthetic injected (t1), after one minute (t2) and after 45 minutes (t3) from capsaicin application. Results. The vascular in vivo observation, in the group A, allows to highlight after one minute application only, the axono reflected vasodilation, the real expression of NP. After 45 minutes, the vascular diameter returned to its initial diameter. In the group B, the vascular in vivo study allows to observe no significant modification of the vascular diameter in the four different time periods. Conclusions. The study highlights that the NP can be induced at the human oral cavity level and such an evidence could be extremely important in the pathogenesis and treatment of the different oral pathologies.
Lingua originaleEnglish
pagine (da-a)707-711
Numero di pagine5
RivistaMethods and Findings in Experimental and Clinical Pharmacology
Volume28
Stato di pubblicazionePublished - 2006

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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