TY - JOUR
T1 - Tolerability and efficacy of high-dose furosemide and small-volume hypertonic saline solution in refractory congestive heart failure
AU - Dominguez Rodriguez, Ligia Juliana
AU - Pinto, Antonio
AU - Licata, Giuseppe
AU - Parrinello, Gaspare
AU - Paterna, Salvatore
AU - Licata, Anna
AU - Paterna, Salvatore
AU - Cardinale, Antonietta
AU - Maniscalchi, Tiziana
AU - Amato, Vincenzo
PY - 1999
Y1 - 1999
N2 - Thirty patients aged 65-85 years, with refractory New York Heart Association (NYHA) class IV congestive heart failure (CHF) were treated with an intravenous infusion of furosemide (250-2000 mg/d) and small-volume hypertonic saline solution (150 mL of 1.4-4.6% NaCl) twice a day for 6 to 12 days. A daily fluid oral intake of 1000 mL and previous cardiac therapy were maintained. Clinical signs and symptoms of CHF, such as dyspnea, edema and weakness, improved, as did severity of illness as defined by NYHA class. The infusion was well tolerated. After a 12-month follow-up, 24 patients (80%) were alive and in the NYHA class assigned on discharge from the hospital. This therapeutic combination is effective and well tolerated and should represent an innovative approach to the management of refractory CHF.
AB - Thirty patients aged 65-85 years, with refractory New York Heart Association (NYHA) class IV congestive heart failure (CHF) were treated with an intravenous infusion of furosemide (250-2000 mg/d) and small-volume hypertonic saline solution (150 mL of 1.4-4.6% NaCl) twice a day for 6 to 12 days. A daily fluid oral intake of 1000 mL and previous cardiac therapy were maintained. Clinical signs and symptoms of CHF, such as dyspnea, edema and weakness, improved, as did severity of illness as defined by NYHA class. The infusion was well tolerated. After a 12-month follow-up, 24 patients (80%) were alive and in the NYHA class assigned on discharge from the hospital. This therapeutic combination is effective and well tolerated and should represent an innovative approach to the management of refractory CHF.
KW - 80 and over; Diuretics; Female; Furosemide; Heart Failure; Humans; Infusions
KW - Aged; Aged
KW - Hypertonic; Statistics
KW - Intravenous; Italy; Male; Saline Solution
KW - Nonparametric; Survival Rate
KW - 80 and over; Diuretics; Female; Furosemide; Heart Failure; Humans; Infusions
KW - Aged; Aged
KW - Hypertonic; Statistics
KW - Intravenous; Italy; Male; Saline Solution
KW - Nonparametric; Survival Rate
UR - http://hdl.handle.net/10447/215777
M3 - Article
VL - 16
SP - 219
EP - 228
JO - Advances in Therapy
JF - Advances in Therapy
SN - 0741-238X
ER -