TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction.

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13 Citazioni (Scopus)

Abstract

Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human population. Proinflammatory genotype may be beneficial in early life but not in old people. With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI). Several studies have looked for detecting a genetic risk profile that might allow a pharmacogenomic approach to prevent and treat age-related diseases such as MI. We have evaluated the possible association between two polymorphisms of TLR2 gene—Arg677Trp and Arg753Gln—and MI. However, we found no association between TLR2 polymorphisms and MI.
Lingua originaleEnglish
pagine (da-a)293-296
Numero di pagine4
RivistaRejuvenation Research
Volume11
Stato di pubblicazionePublished - 2008

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Myocardial Infarction
Pharmacogenetics
Innate Immunity
Genes
Immune System
Atherosclerosis
Homeostasis
Genotype
Inflammation
Phenotype
Population

All Science Journal Classification (ASJC) codes

  • Ageing

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title = "TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction.",
abstract = "Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human population. Proinflammatory genotype may be beneficial in early life but not in old people. With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI). Several studies have looked for detecting a genetic risk profile that might allow a pharmacogenomic approach to prevent and treat age-related diseases such as MI. We have evaluated the possible association between two polymorphisms of TLR2 gene—Arg677Trp and Arg753Gln—and MI. However, we found no association between TLR2 polymorphisms and MI.",
keywords = "TLR2,age-related diseases,polymorphisms,acute myocardial infarction.",
author = "Gregorio Caimi and Calogero Caruso and Enrico Hoffmann and Giuseppina Candore and Domenico Lio and Egle Incalcaterra and Balistreri, {Carmela Rita} and Monica Mirabile and Marco Caruso",
year = "2008",
language = "English",
volume = "11",
pages = "293--296",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert Inc.",

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TY - JOUR

T1 - TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction.

AU - Caimi, Gregorio

AU - Caruso, Calogero

AU - Hoffmann, Enrico

AU - Candore, Giuseppina

AU - Lio, Domenico

AU - Incalcaterra, Egle

AU - Balistreri, Carmela Rita

AU - Mirabile, Monica

AU - Caruso, Marco

PY - 2008

Y1 - 2008

N2 - Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human population. Proinflammatory genotype may be beneficial in early life but not in old people. With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI). Several studies have looked for detecting a genetic risk profile that might allow a pharmacogenomic approach to prevent and treat age-related diseases such as MI. We have evaluated the possible association between two polymorphisms of TLR2 gene—Arg677Trp and Arg753Gln—and MI. However, we found no association between TLR2 polymorphisms and MI.

AB - Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human population. Proinflammatory genotype may be beneficial in early life but not in old people. With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI). Several studies have looked for detecting a genetic risk profile that might allow a pharmacogenomic approach to prevent and treat age-related diseases such as MI. We have evaluated the possible association between two polymorphisms of TLR2 gene—Arg677Trp and Arg753Gln—and MI. However, we found no association between TLR2 polymorphisms and MI.

KW - TLR2,age-related diseases,polymorphisms,acute myocardial infarction.

UR - http://hdl.handle.net/10447/45506

M3 - Article

VL - 11

SP - 293

EP - 296

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

ER -