Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction

Antonio D'Amore, Antonio D'Amore, Jason Tchao, Hongbin Jiang, Yang Zhu, William R. Wagner, Tomo Yoshizumi, Hirokazu Sakaguchi, Kimimasa Tobita

    Risultato della ricerca: Article

    28 Citazioni (Scopus)

    Abstract

    Intramyocardial injection of various injectable hydrogel materials has shown benefit in positively impacting the course of left ventricular (LV) remodeling after myocardial infarction (MI). However, since LV remodeling is a complex, time dependent process, the most efficacious time of hydrogel injection is not clear. In this study, we injected a relatively stiff, thermoresponsive and bioabsorbable hydrogel in rat hearts at 3 different time points - immediately after MI (IM), 3 d post-MI (3D), and 2 w post-MI (2W), corresponding to the beginnings of the necrotic, fibrotic and chronic remodeling phases. The employed left anterior descending coronary artery ligation model showed expected infarction responses including functional loss, inflammation and fibrosis with distinct time dependent patterns. Changes in LV geometry and contractile function were followed by longitudinal echocardiography for 10 w post-MI. While all injection times positively affected LV function and wall thickness, the 3D group gave better functional outcomes than the other injection times and also exhibited more local vascularization and less inflammatory markers than the earlier injection time. The results indicate an important role for injection timing in the increasingly explored concept of post-MI biomaterial injection therapy and suggest that for hydrogels with mechanical support as primary function, injection at the beginning of the fibrotic phase may provide improved outcomes.
    Lingua originaleEnglish
    pagine (da-a)182-193
    Numero di pagine12
    RivistaBiomaterials
    Volume83
    Stato di pubblicazionePublished - 2016

      Fingerprint

    All Science Journal Classification (ASJC) codes

    • Bioengineering
    • Ceramics and Composites
    • Biophysics
    • Biomaterials
    • Mechanics of Materials

    Cita questo

    D'Amore, A., D'Amore, A., Tchao, J., Jiang, H., Zhu, Y., Wagner, W. R., Yoshizumi, T., Sakaguchi, H., & Tobita, K. (2016). Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction. Biomaterials, 83, 182-193.