Three-layered porous device in PCL/PEG blend for interface tissue engineering

Risultato della ricerca: Otherpeer review

Abstract

Tissue interfaces, such as cartilage-to-bone, exhibit anisotropicstructural properties, which gradually vary from one tissue to another.Consequentlya regenerative scaffold designed for interface tissues shouldexhibit a gradient in composition, structure and mechanical features, mimickingthose of the native zones. In particular, the architecture of pores playsa central role. Indeed, a biomedical implant should be designed with porosityand pore size gradients simulating the structure of the two interface tissues.One of the most common techniques to prepare porous scaffolds is the particulateleaching method, which involves the selective leaching of a mineralor organic compound as porogen agents. The main advantage of particulateleaching methods is the effective control of porosity and pore size by variationof the amount and size of leachable particles.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2016

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