THIOPYRANO[2,3-E]INDOL-2-ONES: ANGELICIN HETEROANALOGUES WITH POTENT PHOTOANTIPROLIFERATIVE ACTIVITY

Girolamo Cirrincione, Patrizia Diana, Paola Barraja, Alessandra Montalbano, Anna Carbone, Alessia Salvador, Daniela Vedaldi, Francesco Dall'Acqua, Giampietro Viola

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)

Abstract

A new class of compounds, the thiopyrano[2,3-e ]indol-2-ones, bioisosters of the angular furocoumarin angelicin, was synthesized with the aim of obtaining new photochemotherapeutic agents. In particular 7,8-dimethyl-thiopyranoindolone 6c s showed a remarkable phototoxicity and a great dose UVA dependence reaching IC50 values at submicromolar level. This latter photoinduced a massive apoptosis and a remarkable photodamage to lipids and proteins. Although it did not intercalate DNA, it was able to cause photooxidation of DNA bases.
Lingua originaleEnglish
pagine (da-a)9668-9683
Numero di pagine16
RivistaBIOORGANIC & MEDICINAL CHEMISTRY
Volume16
Stato di pubblicazionePublished - 2008

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1300.1303???
  • ???subjectarea.asjc.1300.1313???
  • ???subjectarea.asjc.1300.1312???
  • ???subjectarea.asjc.3000.3003???
  • ???subjectarea.asjc.3000.3002???
  • ???subjectarea.asjc.1300.1308???
  • ???subjectarea.asjc.1600.1605???

Fingerprint

Entra nei temi di ricerca di 'THIOPYRANO[2,3-E]INDOL-2-ONES: ANGELICIN HETEROANALOGUES WITH POTENT PHOTOANTIPROLIFERATIVE ACTIVITY'. Insieme formano una fingerprint unica.

Cita questo