Anti-virulence strategy is currently considered a promising approach to overcome theglobal threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilmformation is recognized as one of the most relevant. Considering the high and growing percentageof multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable ofcounteracting the formation of biofilms are urgently required. In this scenario, a new series of18 thiazole derivatives was efficiently synthesized and evaluated for its ability to inhibit biofilmformation against the Gram-positive bacterial reference strains Staphylococcus aureus ATCC 25923and S. aureus ATCC 6538 and the Gram-negative strain Pseudomonas aeruginosa ATCC 15442. Most ofthe new compounds showed a marked selectivity against the Gram-positive strains. Remarkably,five compounds exhibited BIC50 values against S. aureus ATCC 25923 ranging from 1.0 to 9.1 M.The new compounds, affecting the biofilm formation without any interference on microbial growth,can be considered promising lead compounds for the development of a new class of anti-virulenceagents.
|Numero di pagine||16|
|Stato di pubblicazione||Published - 2021|
All Science Journal Classification (ASJC) codes