Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection.

Pier Luigi Almasio, Alessio Aghemo, Cirrincione, Elisa Biliotti, Zacharia, Alfredo Alberti, Giovanni Battista Gaeta, Annarosa Floreani, Secchi, Bartolozzi, Rucci, Secchi, Maria Chiaramonte, Gloria Taliani, Marcello Persico, Rosa Cristina Coppola, Nicola Caporaso, Mele, Versace

Risultato della ricerca: Article

14 Citazioni (Scopus)

Abstract

SUMMARY. Hepatitis C virus (HCV) infection is associatedwith a significant reduction of health related quality of life(QOL), the causes and mechanisms of which are still unknown.To explore whether treatment history could affectQOL, we examined patients with detectable HCV viraemiawho had a different therapeutic background. Two hundredsixty-four consecutive subjects with chronic HCV infectionand detectable viraemia were enrolled. Of these, 163 wereuntreated patients, 43 were relapsers, 58 were nonresponders(NR) to nonpegylated interferon (IFN) therapy.To assess QOL, three self-report instruments were employed:the Short Form-36 (SF-36), the Chronic LiverDisease Questionnaire (CLDQ-I) and the World HealthOrganization Quality of Life assessment (WHOQOL-BREF).Clinical and demographic data were collected, and theQOL scores of HCV-positive patients were compared withthose of an Italian normative sample and healthy controls.Further antiviral treatment was offered to untreated andrelapsed patients but not to NR. All patient groups displayedlower QOL scores compared with the normativesample and controls. NR displayed lower QOL scores inseveral areas compared with untreated patients andrelapsers. In multivariate regression analyses, being NRand having a physical comorbidity were significantlyassociated with poorer QOL. Conclusions: Treatment historyand expectations and physical comorbidity may affectQOL in HCV-positive patients. Untreated and relapsedpatients have comparable levels of QOL and higher scoresthan NR.
Lingua originaleEnglish
pagine (da-a)875-882
Numero di pagine8
RivistaJournal of Viral Hepatitis
Volume14
Stato di pubblicazionePublished - 2007

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Chronic Hepatitis C
Virus Diseases
Hepacivirus
Comorbidity
Quality of Life
Therapeutics
Viremia
Self Report
Interferons
Antiviral Agents
Multivariate Analysis
History
Regression Analysis
Demography

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases
  • Virology

Cita questo

Almasio, P. L., Aghemo, A., Cirrincione, Biliotti, E., Zacharia, Alberti, A., ... Versace (2007). Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection. Journal of Viral Hepatitis, 14, 875-882.

Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection. / Almasio, Pier Luigi; Aghemo, Alessio; Cirrincione; Biliotti, Elisa; Zacharia; Alberti, Alfredo; Gaeta, Giovanni Battista; Floreani, Annarosa; Secchi; Bartolozzi; Rucci; Secchi; Chiaramonte, Maria; Taliani, Gloria; Persico, Marcello; Coppola, Rosa Cristina; Caporaso, Nicola; Mele; Versace.

In: Journal of Viral Hepatitis, Vol. 14, 2007, pag. 875-882.

Risultato della ricerca: Article

Almasio, PL, Aghemo, A, Cirrincione, Biliotti, E, Zacharia, Alberti, A, Gaeta, GB, Floreani, A, Secchi, Bartolozzi, Rucci, Secchi, Chiaramonte, M, Taliani, G, Persico, M, Coppola, RC, Caporaso, N, Mele & Versace 2007, 'Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection.', Journal of Viral Hepatitis, vol. 14, pagg. 875-882.
Almasio, Pier Luigi ; Aghemo, Alessio ; Cirrincione ; Biliotti, Elisa ; Zacharia ; Alberti, Alfredo ; Gaeta, Giovanni Battista ; Floreani, Annarosa ; Secchi ; Bartolozzi ; Rucci ; Secchi ; Chiaramonte, Maria ; Taliani, Gloria ; Persico, Marcello ; Coppola, Rosa Cristina ; Caporaso, Nicola ; Mele ; Versace. / Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection. In: Journal of Viral Hepatitis. 2007 ; Vol. 14. pagg. 875-882.
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title = "Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection.",
abstract = "SUMMARY. Hepatitis C virus (HCV) infection is associatedwith a significant reduction of health related quality of life(QOL), the causes and mechanisms of which are still unknown.To explore whether treatment history could affectQOL, we examined patients with detectable HCV viraemiawho had a different therapeutic background. Two hundredsixty-four consecutive subjects with chronic HCV infectionand detectable viraemia were enrolled. Of these, 163 wereuntreated patients, 43 were relapsers, 58 were nonresponders(NR) to nonpegylated interferon (IFN) therapy.To assess QOL, three self-report instruments were employed:the Short Form-36 (SF-36), the Chronic LiverDisease Questionnaire (CLDQ-I) and the World HealthOrganization Quality of Life assessment (WHOQOL-BREF).Clinical and demographic data were collected, and theQOL scores of HCV-positive patients were compared withthose of an Italian normative sample and healthy controls.Further antiviral treatment was offered to untreated andrelapsed patients but not to NR. All patient groups displayedlower QOL scores compared with the normativesample and controls. NR displayed lower QOL scores inseveral areas compared with untreated patients andrelapsers. In multivariate regression analyses, being NRand having a physical comorbidity were significantlyassociated with poorer QOL. Conclusions: Treatment historyand expectations and physical comorbidity may affectQOL in HCV-positive patients. Untreated and relapsedpatients have comparable levels of QOL and higher scoresthan NR.",
author = "Almasio, {Pier Luigi} and Alessio Aghemo and Cirrincione and Elisa Biliotti and Zacharia and Alfredo Alberti and Gaeta, {Giovanni Battista} and Annarosa Floreani and Secchi and Bartolozzi and Rucci and Secchi and Maria Chiaramonte and Gloria Taliani and Marcello Persico and Coppola, {Rosa Cristina} and Nicola Caporaso and Mele and Versace",
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T1 - Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection.

AU - Almasio, Pier Luigi

AU - Aghemo, Alessio

AU - Cirrincione, null

AU - Biliotti, Elisa

AU - Zacharia, null

AU - Alberti, Alfredo

AU - Gaeta, Giovanni Battista

AU - Floreani, Annarosa

AU - Secchi, null

AU - Bartolozzi, null

AU - Rucci, null

AU - Secchi, null

AU - Chiaramonte, Maria

AU - Taliani, Gloria

AU - Persico, Marcello

AU - Coppola, Rosa Cristina

AU - Caporaso, Nicola

AU - Mele, null

AU - Versace, null

PY - 2007

Y1 - 2007

N2 - SUMMARY. Hepatitis C virus (HCV) infection is associatedwith a significant reduction of health related quality of life(QOL), the causes and mechanisms of which are still unknown.To explore whether treatment history could affectQOL, we examined patients with detectable HCV viraemiawho had a different therapeutic background. Two hundredsixty-four consecutive subjects with chronic HCV infectionand detectable viraemia were enrolled. Of these, 163 wereuntreated patients, 43 were relapsers, 58 were nonresponders(NR) to nonpegylated interferon (IFN) therapy.To assess QOL, three self-report instruments were employed:the Short Form-36 (SF-36), the Chronic LiverDisease Questionnaire (CLDQ-I) and the World HealthOrganization Quality of Life assessment (WHOQOL-BREF).Clinical and demographic data were collected, and theQOL scores of HCV-positive patients were compared withthose of an Italian normative sample and healthy controls.Further antiviral treatment was offered to untreated andrelapsed patients but not to NR. All patient groups displayedlower QOL scores compared with the normativesample and controls. NR displayed lower QOL scores inseveral areas compared with untreated patients andrelapsers. In multivariate regression analyses, being NRand having a physical comorbidity were significantlyassociated with poorer QOL. Conclusions: Treatment historyand expectations and physical comorbidity may affectQOL in HCV-positive patients. Untreated and relapsedpatients have comparable levels of QOL and higher scoresthan NR.

AB - SUMMARY. Hepatitis C virus (HCV) infection is associatedwith a significant reduction of health related quality of life(QOL), the causes and mechanisms of which are still unknown.To explore whether treatment history could affectQOL, we examined patients with detectable HCV viraemiawho had a different therapeutic background. Two hundredsixty-four consecutive subjects with chronic HCV infectionand detectable viraemia were enrolled. Of these, 163 wereuntreated patients, 43 were relapsers, 58 were nonresponders(NR) to nonpegylated interferon (IFN) therapy.To assess QOL, three self-report instruments were employed:the Short Form-36 (SF-36), the Chronic LiverDisease Questionnaire (CLDQ-I) and the World HealthOrganization Quality of Life assessment (WHOQOL-BREF).Clinical and demographic data were collected, and theQOL scores of HCV-positive patients were compared withthose of an Italian normative sample and healthy controls.Further antiviral treatment was offered to untreated andrelapsed patients but not to NR. All patient groups displayedlower QOL scores compared with the normativesample and controls. NR displayed lower QOL scores inseveral areas compared with untreated patients andrelapsers. In multivariate regression analyses, being NRand having a physical comorbidity were significantlyassociated with poorer QOL. Conclusions: Treatment historyand expectations and physical comorbidity may affectQOL in HCV-positive patients. Untreated and relapsedpatients have comparable levels of QOL and higher scoresthan NR.

UR - http://hdl.handle.net/10447/24664

M3 - Article

VL - 14

SP - 875

EP - 882

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

SN - 1352-0504

ER -