SUMMARY. Hepatitis C virus (HCV) infection is associatedwith a significant reduction of health related quality of life(QOL), the causes and mechanisms of which are still unknown.To explore whether treatment history could affectQOL, we examined patients with detectable HCV viraemiawho had a different therapeutic background. Two hundredsixty-four consecutive subjects with chronic HCV infectionand detectable viraemia were enrolled. Of these, 163 wereuntreated patients, 43 were relapsers, 58 were nonresponders(NR) to nonpegylated interferon (IFN) therapy.To assess QOL, three self-report instruments were employed:the Short Form-36 (SF-36), the Chronic LiverDisease Questionnaire (CLDQ-I) and the World HealthOrganization Quality of Life assessment (WHOQOL-BREF).Clinical and demographic data were collected, and theQOL scores of HCV-positive patients were compared withthose of an Italian normative sample and healthy controls.Further antiviral treatment was offered to untreated andrelapsed patients but not to NR. All patient groups displayedlower QOL scores compared with the normativesample and controls. NR displayed lower QOL scores inseveral areas compared with untreated patients andrelapsers. In multivariate regression analyses, being NRand having a physical comorbidity were significantlyassociated with poorer QOL. Conclusions: Treatment historyand expectations and physical comorbidity may affectQOL in HCV-positive patients. Untreated and relapsedpatients have comparable levels of QOL and higher scoresthan NR.
|Numero di pagine||8|
|Rivista||Journal of Viral Hepatitis|
|Stato di pubblicazione||Published - 2007|