Theoretical and experimental study of the role of cell-cell dipole interaction in dielectrophoretic devices: application to polynomial electrodes.

Valentina Bravata', Luigi Minafra, Massimo Camarda, Ruggero Anzalone, Giuseppe Fisicaro, Maria C. Gilardi, Giorgio Russo, Valentina Bravatà, Francesco P. Cammarata, Andrea Ballo, Silvia Scalese, Antonino La Magna, Giusi I. Forte, Gianluca Giustolisi, Francesco La Via, Alessandra Alberti

    Risultato della ricerca: Articlepeer review

    15 Citazioni (Scopus)

    Abstract

    BackgroundWe aimed to investigate the effect of cell-cell dipole interactions in the equilibrium distributions in dielectrophoretic devices.MethodsWe used a three dimensional coupled Monte Carlo-Poisson method to theoretically study the final distribution of a system of uncharged polarizable particles suspended in a static liquid medium under the action of an oscillating non-uniform electric field generated by polynomial electrodes. The simulated distributions have been compared with experimental ones observed in the case of MDA-MB-231 cells in the same operating conditions.ResultsThe real and simulated distributions are consistent. In both cases the cells distribution near the electrodes is dominated by cell-cell dipole interactions which generate long chains.ConclusionsThe agreement between real and simulated cells’ distributions demonstrate the method’s reliability. The distribution are dominated by cell-cell dipole interactions even at low density regimes (105 cell/ml). An improved estimate for the density threshold governing the interaction free regime is suggested.
    Lingua originaleEnglish
    Numero di pagine10
    RivistaBioMedical Engineering Online
    Volume5(13)
    Stato di pubblicazionePublished - 2014

    All Science Journal Classification (ASJC) codes

    • Medicine(all)
    • Radiological and Ultrasound Technology
    • Biomaterials
    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

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