Neuroimaging and lesion studies have documented the involvement of the frontal lobes in recognitionmemory. However, the precise nature of prefrontal contributions to verbal and non-verbal memory and tofamiliarity and recollection processes remains unclear. The aim of the current rTMS study was to investigatefor the first time the role of the DLPFC in encoding and retrieval of non-verbal and verbal memoranda and itscontribution to recollection and familiarity processes. Recollection and familiarity processes were studiedusing the ROC and unequal variance signal detection methodologies. We found that rTMS delivered over leftand right DLPFC at encoding resulted in material specific laterality effects with a disruption of recognition ofverbal and non-verbal memoranda. Interestingly, rTMS over DLPFCs at encoding significantly affected bothrecollection and familiarity. However, at retrieval rTMS did not affect recollection and familiarity. Our resultssuggest that DLPFC has a degree of functional specialisation and plays an important role in the encoding ofverbal and non-verbal memoranda.
|Numero di pagine||10|
|Stato di pubblicazione||Published - 2010|
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