TY - JOUR
T1 - The role of targeted therapy for gastrointestinal tumors
AU - Bronte, Giuseppe
AU - Russo, Antonio
AU - Passiglia, Francesco
AU - Papadimitriou, Konstantinos
AU - Fiorentino, Eugenio
AU - Peeters, Marc
AU - Papadimitriou, Konstantinos
AU - Passiglia, Francesco
AU - Rolfo, Christian
AU - Marogy, Ghada
AU - Sortino, Giovanni
PY - 2014
Y1 - 2014
N2 - Many targeted drugs have been studied to target the molecular pathways involved in the development of gastrointestinal cancers. Anti-VEGF, anti-EGFR agents, and recently also multi-kinase inhibitor regorafenib, have already been available for the treatment of metastatic colorectal cancer patients. To date, Her-2 positive, gastric cancer patients, are also treated with trastuzumab, while the multi-targeted inhibitor, sorafenib, represents the standard treatment for hepatocellular carcinoma patients. Finally, sunitinib and everolimus, have been approved for the treatment of the neuroendocrine gastroenteropancreatic tumors. Actually a great number of further drugs are under preclinical and clinical development. The aim of this review is to provide a comprehensive overview of the state of art, focusing on the new emerging strategies in the personalized treatment of gastrointestinal tumors.
AB - Many targeted drugs have been studied to target the molecular pathways involved in the development of gastrointestinal cancers. Anti-VEGF, anti-EGFR agents, and recently also multi-kinase inhibitor regorafenib, have already been available for the treatment of metastatic colorectal cancer patients. To date, Her-2 positive, gastric cancer patients, are also treated with trastuzumab, while the multi-targeted inhibitor, sorafenib, represents the standard treatment for hepatocellular carcinoma patients. Finally, sunitinib and everolimus, have been approved for the treatment of the neuroendocrine gastroenteropancreatic tumors. Actually a great number of further drugs are under preclinical and clinical development. The aim of this review is to provide a comprehensive overview of the state of art, focusing on the new emerging strategies in the personalized treatment of gastrointestinal tumors.
UR - http://hdl.handle.net/10447/109880
UR - http://www.future-drugs.com/page/journal/egh/teaser.jsp
M3 - Article
VL - 8
SP - 875
EP - 885
JO - EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
JF - EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
SN - 1747-4124
ER -