The role of targeted therapy for gastrointestinal tumors

Eugenio Fiorentino, Francesco Passiglia, Konstantinos Papadimitriou, Antonio Russo, Giuseppe Bronte, Marc Peeters, Konstantinos Papadimitriou, Francesco Passiglia, Christian Rolfo, Ghada Marogy, Giovanni Sortino

Risultato della ricerca: Article

26 Citazioni (Scopus)

Abstract

Many targeted drugs have been studied to target the molecular pathways involved in the development of gastrointestinal cancers. Anti-VEGF, anti-EGFR agents, and recently also multi-kinase inhibitor regorafenib, have already been available for the treatment of metastatic colorectal cancer patients. To date, Her-2 positive, gastric cancer patients, are also treated with trastuzumab, while the multi-targeted inhibitor, sorafenib, represents the standard treatment for hepatocellular carcinoma patients. Finally, sunitinib and everolimus, have been approved for the treatment of the neuroendocrine gastroenteropancreatic tumors. Actually a great number of further drugs are under preclinical and clinical development. The aim of this review is to provide a comprehensive overview of the state of art, focusing on the new emerging strategies in the personalized treatment of gastrointestinal tumors.
Lingua originaleEnglish
pagine (da-a)875-885
Numero di pagine11
RivistaEXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
Volume8
Stato di pubblicazionePublished - 2014

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Neoplasms
Gastrointestinal Neoplasms
Therapeutics
Pharmaceutical Preparations
Vascular Endothelial Growth Factor A
Stomach Neoplasms
Hepatocellular Carcinoma
Colorectal Neoplasms
Phosphotransferases
Everolimus
sorafenib
sunitinib
Trastuzumab
Gastro-enteropancreatic neuroendocrine tumor
regorafenib

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cita questo

The role of targeted therapy for gastrointestinal tumors. / Fiorentino, Eugenio; Passiglia, Francesco; Papadimitriou, Konstantinos; Russo, Antonio; Bronte, Giuseppe; Peeters, Marc; Papadimitriou, Konstantinos; Passiglia, Francesco; Rolfo, Christian; Marogy, Ghada; Sortino, Giovanni.

In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, Vol. 8, 2014, pag. 875-885.

Risultato della ricerca: Article

Fiorentino, Eugenio ; Passiglia, Francesco ; Papadimitriou, Konstantinos ; Russo, Antonio ; Bronte, Giuseppe ; Peeters, Marc ; Papadimitriou, Konstantinos ; Passiglia, Francesco ; Rolfo, Christian ; Marogy, Ghada ; Sortino, Giovanni. / The role of targeted therapy for gastrointestinal tumors. In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY. 2014 ; Vol. 8. pagg. 875-885.
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