TY - JOUR
T1 - The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape.
AU - Romano, Valentino
AU - Denden, Sabri
AU - Haj-Khelil, Amel
AU - Brisighelli, Francesca
AU - Anagnostou, Paolo
AU - Busby, George B.J.
AU - Hayward, Caroline
AU - Nesheva, Desislava
AU - Montinaro, Francesco
AU - Cali, Francesco
AU - Krajewski, Pawel
AU - Zemunik, Tatijana
AU - Karachanak-Yankova, Sena
AU - Wilson, James F.
AU - Buresi, Catherine
AU - Myers, Simon
AU - Rudan, Igor
AU - Hellenthal, Garrett
AU - Ben Chibani, Jemni
AU - Tofanelli, Sergio
AU - Hervig, Tor
AU - Bulayeva, Kazima
AU - Ploski, Rafal
AU - Toncheva, Draga
AU - Capelli, Cristian
AU - Moen, Torolf
AU - Lefranc, Gerard
AU - Rudan, Igor
AU - Herrera, Rene J.
PY - 2015
Y1 - 2015
N2 - Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-scale, dynamic population movements over the last 10,000 years, such that ancestry across present-day populations is likely to be a mixture of several ancient groups [1-7]. While these efforts are bringing the details of West Eurasian prehistory into increasing focus, studies aimed at understanding the processes behind the generation of the current West Eurasian genetic landscape have been limited by the number of populations sampled or have been either too regional or global in their outlook [8-11]. Here, using recently described haplotype-based techniques [11], we present the results of a systematic survey of recent admixture history across Western Eurasia and show that admixture is a universal property across almost all groups. Admixture in all regions except North Western Europe involved the influx of genetic material from outside of West Eurasia, which we date to specific time periods. Within Northern, Western, and Central Europe, admixture tended to occur between local groups during the period 300 to 1200 CE. Comparisons of the genetic profiles of West Eurasians before and after admixture show that population movements within the last 1,500 years are likely to have maintained differentiation among groups. Our analysis provides a timeline of the gene flow events that have generated the contemporary genetic landscape of West Eurasia.
AB - Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-scale, dynamic population movements over the last 10,000 years, such that ancestry across present-day populations is likely to be a mixture of several ancient groups [1-7]. While these efforts are bringing the details of West Eurasian prehistory into increasing focus, studies aimed at understanding the processes behind the generation of the current West Eurasian genetic landscape have been limited by the number of populations sampled or have been either too regional or global in their outlook [8-11]. Here, using recently described haplotype-based techniques [11], we present the results of a systematic survey of recent admixture history across Western Eurasia and show that admixture is a universal property across almost all groups. Admixture in all regions except North Western Europe involved the influx of genetic material from outside of West Eurasia, which we date to specific time periods. Within Northern, Western, and Central Europe, admixture tended to occur between local groups during the period 300 to 1200 CE. Comparisons of the genetic profiles of West Eurasians before and after admixture show that population movements within the last 1,500 years are likely to have maintained differentiation among groups. Our analysis provides a timeline of the gene flow events that have generated the contemporary genetic landscape of West Eurasia.
UR - http://hdl.handle.net/10447/264201
M3 - Article
VL - 25
SP - 2518
EP - 2526
JO - Current Biology
JF - Current Biology
SN - 0960-9822
ER -