TY - JOUR
T1 - The Role of Nutraceuticals in Statin Intolerant Patients
AU - Patti, Angelo Maria
AU - Nikolic, Dragana
AU - Rizzo, Manfredi
AU - Giglio, Rosaria Vincenza
AU - Bajraktari, Gani
AU - Banach, Maciej
AU - Katsiki, Niki
AU - Sahebkar, Amirhossein
AU - Rosano, Giuseppe M.C.
AU - Pitsavos, Christos
AU - Fras, Zlatko
AU - Djuric, Dragan M.
AU - Mikhailidis, Dimitri P.
AU - Paulweber, Bernhard
AU - Reiner, Željko
AU - Bruckert, Eric
AU - Langlois, Michel
AU - Serban, Maria-Corina
AU - Paragh, Gyorgy
AU - Mitchenko, Olena
AU - Pella, Daniel
AU - Ezhov, Marat
AU - Mitchenko, Olena
AU - Rosano, Giuseppe M.C.
AU - Latkovskis, Gustavs
AU - Von Haehling, Stephan
AU - Vinereanu, Dragos
AU - Vrablík, Michal
AU - Descamps, Olivier
AU - Paragh, Gyorgy
AU - Cicero, Arrigo F.G.
AU - Muntner, Paul
AU - Rysz, Jacek
AU - Panagiotakos, Demosthenes B.
AU - Moriarty, Patrick M.
AU - Rosenson, Robert S.
AU - Rosano, Giuseppe M.C.
AU - Atanasov, Atanas G.
AU - Watts, Gerald F.
AU - Wong, Nathan D.
AU - Mancini, G.B. John
PY - 2018
Y1 - 2018
N2 - Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment. These nutraceuticals could exert significant lipid-lowering activity and might present multiple non–lipid-lowering actions, including improvement of endothelial dysfunction and arterial stiffness, as well as anti-inflammatory and antioxidative properties. The aim of this expert opinion paper is to provide the first attempt at recommendation on the management of statin intolerance through the use of nutraceuticals with particular attention on those with effective low-density lipoprotein cholesterol reduction.
AB - Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment. These nutraceuticals could exert significant lipid-lowering activity and might present multiple non–lipid-lowering actions, including improvement of endothelial dysfunction and arterial stiffness, as well as anti-inflammatory and antioxidative properties. The aim of this expert opinion paper is to provide the first attempt at recommendation on the management of statin intolerance through the use of nutraceuticals with particular attention on those with effective low-density lipoprotein cholesterol reduction.
UR - http://hdl.handle.net/10447/433774
M3 - Article
SN - 0735-1097
VL - 72
SP - 96
EP - 118
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
ER -