The role of macrophages polarization in predicting prognosis of radically resected gastric cancer patients

Antonio Russo, Sergio Rizzo, Marco Caricato, Bruno Vincenzi, Francesco Graziano, Giuseppe Tonini, Daniele Santini, Francesco Pantano, Francesco Maria Guida, Pierpaolo Berti, Michelina Maria Carla Amato, Emanuela Dell'Aquila, Andrea Onetti Muda, Vincenzo Catalano, Giuseppe Perrone, Daniela Righi

Risultato della ricerca: Article

33 Citazioni (Scopus)

Abstract

Tumour-associated Macrophages (TAM) present two different polarizations: classical (M1) characterized by immunostimulation activity and tumour suppression; alternative (M2) characterized by tumour promotion and immune suppression. In this retrospective study, we evaluated the correlation between the two forms of TAM with survival time in radically resected gastric cancer patients. A total of 52 chemo- and radio- naive patients were included. Two slides were prepared for each patient and double-stained for CD68/NOS2 (M1) or CD68/CD163 (M2) and five representative high-power fields per slide were evaluated for TAM count. The median value of the two macrophage populations density and the median value of M1/M2 ratio were used as cut-off. Twenty-seven patients with M1 density above-the-median had a significantly higher survival compared to those below the median. Twenty-six patients with M1/M2 ratio above the median showed median OS of 27.2 months compared to 15.5 months of the patients below the median. No association between M2 macrophage density and patient’s outcome was found. In multivariate analysis, M1/M2 was a positive independent predictor of survival. The M1 macrophage density and M1/M2 ratio, as con- firmed in multivariate analysis, are factors that can help in predicting patients survival time after radical surgery for gastric cancer
Lingua originaleEnglish
pagine (da-a)1415-1421
Numero di pagine7
RivistaJournal of Cellular and Molecular Medicine
Volume17
Stato di pubblicazionePublished - 2013

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Stomach Neoplasms
Macrophages
Survival
Neoplasms
Multivariate Analysis
Population Density
Radio
Immunization
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cell Biology

Cita questo

The role of macrophages polarization in predicting prognosis of radically resected gastric cancer patients. / Russo, Antonio; Rizzo, Sergio; Caricato, Marco; Vincenzi, Bruno; Graziano, Francesco; Tonini, Giuseppe; Santini, Daniele; Pantano, Francesco; Guida, Francesco Maria; Berti, Pierpaolo; Amato, Michelina Maria Carla; Dell'Aquila, Emanuela; Muda, Andrea Onetti; Catalano, Vincenzo; Perrone, Giuseppe; Righi, Daniela.

In: Journal of Cellular and Molecular Medicine, Vol. 17, 2013, pag. 1415-1421.

Risultato della ricerca: Article

Russo, A, Rizzo, S, Caricato, M, Vincenzi, B, Graziano, F, Tonini, G, Santini, D, Pantano, F, Guida, FM, Berti, P, Amato, MMC, Dell'Aquila, E, Muda, AO, Catalano, V, Perrone, G & Righi, D 2013, 'The role of macrophages polarization in predicting prognosis of radically resected gastric cancer patients', Journal of Cellular and Molecular Medicine, vol. 17, pagg. 1415-1421.
Russo, Antonio ; Rizzo, Sergio ; Caricato, Marco ; Vincenzi, Bruno ; Graziano, Francesco ; Tonini, Giuseppe ; Santini, Daniele ; Pantano, Francesco ; Guida, Francesco Maria ; Berti, Pierpaolo ; Amato, Michelina Maria Carla ; Dell'Aquila, Emanuela ; Muda, Andrea Onetti ; Catalano, Vincenzo ; Perrone, Giuseppe ; Righi, Daniela. / The role of macrophages polarization in predicting prognosis of radically resected gastric cancer patients. In: Journal of Cellular and Molecular Medicine. 2013 ; Vol. 17. pagg. 1415-1421.
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abstract = "Tumour-associated Macrophages (TAM) present two different polarizations: classical (M1) characterized by immunostimulation activity and tumour suppression; alternative (M2) characterized by tumour promotion and immune suppression. In this retrospective study, we evaluated the correlation between the two forms of TAM with survival time in radically resected gastric cancer patients. A total of 52 chemo- and radio- naive patients were included. Two slides were prepared for each patient and double-stained for CD68/NOS2 (M1) or CD68/CD163 (M2) and five representative high-power fields per slide were evaluated for TAM count. The median value of the two macrophage populations density and the median value of M1/M2 ratio were used as cut-off. Twenty-seven patients with M1 density above-the-median had a significantly higher survival compared to those below the median. Twenty-six patients with M1/M2 ratio above the median showed median OS of 27.2 months compared to 15.5 months of the patients below the median. No association between M2 macrophage density and patient’s outcome was found. In multivariate analysis, M1/M2 was a positive independent predictor of survival. The M1 macrophage density and M1/M2 ratio, as con- firmed in multivariate analysis, are factors that can help in predicting patients survival time after radical surgery for gastric cancer",
author = "Antonio Russo and Sergio Rizzo and Marco Caricato and Bruno Vincenzi and Francesco Graziano and Giuseppe Tonini and Daniele Santini and Francesco Pantano and Guida, {Francesco Maria} and Pierpaolo Berti and Amato, {Michelina Maria Carla} and Emanuela Dell'Aquila and Muda, {Andrea Onetti} and Vincenzo Catalano and Giuseppe Perrone and Daniela Righi",
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T1 - The role of macrophages polarization in predicting prognosis of radically resected gastric cancer patients

AU - Russo, Antonio

AU - Rizzo, Sergio

AU - Caricato, Marco

AU - Vincenzi, Bruno

AU - Graziano, Francesco

AU - Tonini, Giuseppe

AU - Santini, Daniele

AU - Pantano, Francesco

AU - Guida, Francesco Maria

AU - Berti, Pierpaolo

AU - Amato, Michelina Maria Carla

AU - Dell'Aquila, Emanuela

AU - Muda, Andrea Onetti

AU - Catalano, Vincenzo

AU - Perrone, Giuseppe

AU - Righi, Daniela

PY - 2013

Y1 - 2013

N2 - Tumour-associated Macrophages (TAM) present two different polarizations: classical (M1) characterized by immunostimulation activity and tumour suppression; alternative (M2) characterized by tumour promotion and immune suppression. In this retrospective study, we evaluated the correlation between the two forms of TAM with survival time in radically resected gastric cancer patients. A total of 52 chemo- and radio- naive patients were included. Two slides were prepared for each patient and double-stained for CD68/NOS2 (M1) or CD68/CD163 (M2) and five representative high-power fields per slide were evaluated for TAM count. The median value of the two macrophage populations density and the median value of M1/M2 ratio were used as cut-off. Twenty-seven patients with M1 density above-the-median had a significantly higher survival compared to those below the median. Twenty-six patients with M1/M2 ratio above the median showed median OS of 27.2 months compared to 15.5 months of the patients below the median. No association between M2 macrophage density and patient’s outcome was found. In multivariate analysis, M1/M2 was a positive independent predictor of survival. The M1 macrophage density and M1/M2 ratio, as con- firmed in multivariate analysis, are factors that can help in predicting patients survival time after radical surgery for gastric cancer

AB - Tumour-associated Macrophages (TAM) present two different polarizations: classical (M1) characterized by immunostimulation activity and tumour suppression; alternative (M2) characterized by tumour promotion and immune suppression. In this retrospective study, we evaluated the correlation between the two forms of TAM with survival time in radically resected gastric cancer patients. A total of 52 chemo- and radio- naive patients were included. Two slides were prepared for each patient and double-stained for CD68/NOS2 (M1) or CD68/CD163 (M2) and five representative high-power fields per slide were evaluated for TAM count. The median value of the two macrophage populations density and the median value of M1/M2 ratio were used as cut-off. Twenty-seven patients with M1 density above-the-median had a significantly higher survival compared to those below the median. Twenty-six patients with M1/M2 ratio above the median showed median OS of 27.2 months compared to 15.5 months of the patients below the median. No association between M2 macrophage density and patient’s outcome was found. In multivariate analysis, M1/M2 was a positive independent predictor of survival. The M1 macrophage density and M1/M2 ratio, as con- firmed in multivariate analysis, are factors that can help in predicting patients survival time after radical surgery for gastric cancer

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