TY - JOUR
T1 - The role of innate and lymphoid IL-22-producing cells in the immunopathology of primary Sjögren's syndrome
AU - Guggino, Giuliana
AU - Triolo, Giovanni
AU - Ferrante, Angelo
AU - Ciccia, Francesco
AU - Carrubbi, Francesco
AU - Giacomelli, Roberto
PY - 2014
Y1 - 2014
N2 - In primary Sjögren's syndrome (pSS) a complex of interconnections between epithelial barrier, innate and adaptive immunity occurs. IL-22 is a pleiotropic cytokine that in pSS may be placed at the intersection of the adaptive and innate branches of immunity. Some evidence suggests that, in pSS, IL-22 may play a prominent pro-inflammatory role driving the early phase of tissue and systemic inflammation and participating in the self-perpetuation of disease. Despite contradictory data in literature about the role of NK cells in pSS, recent data also suggest an important contribution of this subset of cells of the innate immune system in the development and perpetuation of inflammation. Here, we discuss the role of IL-22 in the pathogenesis of pSS and in epithelial barrier function.
AB - In primary Sjögren's syndrome (pSS) a complex of interconnections between epithelial barrier, innate and adaptive immunity occurs. IL-22 is a pleiotropic cytokine that in pSS may be placed at the intersection of the adaptive and innate branches of immunity. Some evidence suggests that, in pSS, IL-22 may play a prominent pro-inflammatory role driving the early phase of tissue and systemic inflammation and participating in the self-perpetuation of disease. Despite contradictory data in literature about the role of NK cells in pSS, recent data also suggest an important contribution of this subset of cells of the innate immune system in the development and perpetuation of inflammation. Here, we discuss the role of IL-22 in the pathogenesis of pSS and in epithelial barrier function.
KW - Humans; Interleukins; Killer Cells
KW - Innate
KW - Natural; Sjogren's Syndrome; Adaptive Immunity; Immunity
KW - Humans; Interleukins; Killer Cells
KW - Innate
KW - Natural; Sjogren's Syndrome; Adaptive Immunity; Immunity
UR - http://hdl.handle.net/10447/167327
M3 - Article
VL - 10
SP - 533
EP - 541
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
ER -