8 Citazioni (Scopus)

Abstract

ype A aortic dissection (TAAD) is a severe cardiovascular disease with high mortality rates. Current evidence suggests inflammation as the main mechanism of its complex pathophysiology. Accordingly, in this study the eventual presence of inflammatory cells in aorta specimens and any contribution of these cells in both apoptosis and metalloproteinase levels were assessed. The potential relationship between plasma inflammatory molecules and TAAD was also detected. In addition, implication in TAAD susceptibility of ten common and functional single nucleotide polymorphisms (SNP)s of six candidate genes (CCR5, TLR4, ACE, eNOs, MMP-9 and -2) was determined. Thus, histo-pathological and immunoistochemical aorta examination, TUNEL testing, genotyping of ten SNPs were performed. Levels of plasma inflammatory molecules were also determined using ELISA technique. A significant inflammatory infiltrate was observed in the examined aortas. Consistent with these data, significantly higher plasma levels of systemic inflammatory mediators characterized the cases. In addition, a high risk genotype significantly associated with TAAD susceptibility was identified. Thus, inflammation producing MMPs, cytokines and death mediators seem to be the shared pathological mechanism for TAAD in the population examined
Lingua originaleEnglish
pagine (da-a)269-277
Numero di pagine9
RivistaEuropean Journal of Inflammation
Volume11
Stato di pubblicazionePublished - 2013

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Dissection
Inflammation
Aorta
Matrix Metalloproteinases
Single Nucleotide Polymorphism
In Situ Nick-End Labeling
Metalloproteases
Cardiovascular Diseases
Enzyme-Linked Immunosorbent Assay
Genotype
1,3,4,6-tetra-O-acetyl-2-azido-2-deoxyglucopyranose
Apoptosis
Cytokines
Mortality
Population
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cita questo

THE ROLE OF INFLAMMATION IN TYPE A AORTIC DISSECTION: A PILOT STUDY. / Pisano, C.; D’Amico, T.; Ruvolo, G.

In: European Journal of Inflammation, Vol. 11, 2013, pag. 269-277.

Risultato della ricerca: Article

Pisano, C.; D’Amico, T.; Ruvolo, G. 2013, 'THE ROLE OF INFLAMMATION IN TYPE A AORTIC DISSECTION: A PILOT STUDY', European Journal of Inflammation, vol. 11, pagg. 269-277.
Pisano, C.; D’Amico, T.; Ruvolo, G. / THE ROLE OF INFLAMMATION IN TYPE A AORTIC DISSECTION: A PILOT STUDY. In: European Journal of Inflammation. 2013 ; Vol. 11. pagg. 269-277.
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title = "THE ROLE OF INFLAMMATION IN TYPE A AORTIC DISSECTION: A PILOT STUDY",
abstract = "ype A aortic dissection (TAAD) is a severe cardiovascular disease with high mortality rates. Current evidence suggests inflammation as the main mechanism of its complex pathophysiology. Accordingly, in this study the eventual presence of inflammatory cells in aorta specimens and any contribution of these cells in both apoptosis and metalloproteinase levels were assessed. The potential relationship between plasma inflammatory molecules and TAAD was also detected. In addition, implication in TAAD susceptibility of ten common and functional single nucleotide polymorphisms (SNP)s of six candidate genes (CCR5, TLR4, ACE, eNOs, MMP-9 and -2) was determined. Thus, histo-pathological and immunoistochemical aorta examination, TUNEL testing, genotyping of ten SNPs were performed. Levels of plasma inflammatory molecules were also determined using ELISA technique. A significant inflammatory infiltrate was observed in the examined aortas. Consistent with these data, significantly higher plasma levels of systemic inflammatory mediators characterized the cases. In addition, a high risk genotype significantly associated with TAAD susceptibility was identified. Thus, inflammation producing MMPs, cytokines and death mediators seem to be the shared pathological mechanism for TAAD in the population examined",
author = "{Pisano, C.; D’Amico, T.; Ruvolo, G.} and {Palmeri Di Villalba}, Cesira and Giuseppina Candore and Emiliano Maresi and Balistreri, {Carmela Rita}",
year = "2013",
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T1 - THE ROLE OF INFLAMMATION IN TYPE A AORTIC DISSECTION: A PILOT STUDY

AU - Pisano, C.; D’Amico, T.; Ruvolo, G.

AU - Palmeri Di Villalba, Cesira

AU - Candore, Giuseppina

AU - Maresi, Emiliano

AU - Balistreri, Carmela Rita

PY - 2013

Y1 - 2013

N2 - ype A aortic dissection (TAAD) is a severe cardiovascular disease with high mortality rates. Current evidence suggests inflammation as the main mechanism of its complex pathophysiology. Accordingly, in this study the eventual presence of inflammatory cells in aorta specimens and any contribution of these cells in both apoptosis and metalloproteinase levels were assessed. The potential relationship between plasma inflammatory molecules and TAAD was also detected. In addition, implication in TAAD susceptibility of ten common and functional single nucleotide polymorphisms (SNP)s of six candidate genes (CCR5, TLR4, ACE, eNOs, MMP-9 and -2) was determined. Thus, histo-pathological and immunoistochemical aorta examination, TUNEL testing, genotyping of ten SNPs were performed. Levels of plasma inflammatory molecules were also determined using ELISA technique. A significant inflammatory infiltrate was observed in the examined aortas. Consistent with these data, significantly higher plasma levels of systemic inflammatory mediators characterized the cases. In addition, a high risk genotype significantly associated with TAAD susceptibility was identified. Thus, inflammation producing MMPs, cytokines and death mediators seem to be the shared pathological mechanism for TAAD in the population examined

AB - ype A aortic dissection (TAAD) is a severe cardiovascular disease with high mortality rates. Current evidence suggests inflammation as the main mechanism of its complex pathophysiology. Accordingly, in this study the eventual presence of inflammatory cells in aorta specimens and any contribution of these cells in both apoptosis and metalloproteinase levels were assessed. The potential relationship between plasma inflammatory molecules and TAAD was also detected. In addition, implication in TAAD susceptibility of ten common and functional single nucleotide polymorphisms (SNP)s of six candidate genes (CCR5, TLR4, ACE, eNOs, MMP-9 and -2) was determined. Thus, histo-pathological and immunoistochemical aorta examination, TUNEL testing, genotyping of ten SNPs were performed. Levels of plasma inflammatory molecules were also determined using ELISA technique. A significant inflammatory infiltrate was observed in the examined aortas. Consistent with these data, significantly higher plasma levels of systemic inflammatory mediators characterized the cases. In addition, a high risk genotype significantly associated with TAAD susceptibility was identified. Thus, inflammation producing MMPs, cytokines and death mediators seem to be the shared pathological mechanism for TAAD in the population examined

UR - http://hdl.handle.net/10447/73933

M3 - Article

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JO - European Journal of Inflammation

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