The role of endosomal toll-like receptors in bacterial recognition

Antonio Cascio, Orazio Romeo, Biondo, Teti, Beninati, Mancuso, Cascio, Chiara Iaria

Risultato della ricerca: Articlepeer review

11 Citazioni (Scopus)

Abstract

BACKGROUND: Infections caused by extracellular Gram positive bacteria are still a major health problems. Better understanding of the mechanisms underlying immune responses to these organisms is key to develop pharmacological agents, including vaccines, to control these infections.OBJECTIVE AND PERSPECTIVES: The objective of this review is to highlight the importance of nucleic acid-sensing, intracellular Toll-like receptors in innate immune recognition and in host defenses against extracellular bacteria.CONCLUSIONS: Toll-like receptors 7 and 9 have a major role in inducing host-protective type I interferon responses in conventional dendritic cells in response to streptococci and other extracellular gram positive bacteria. Moreover an as yet unidentified MyD88-dependent receptor is likely responsible for proinflammatory cytokine induction in response to these pathogens.
Lingua originaleEnglish
pagine (da-a)1506-1512
Numero di pagine7
RivistaEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Volume16
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2736???

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