THE ROLE OF BUTYRIC ACID AS A OPROTECTIVE AGENT AGAINST INFLAMMATORY BOWEL DISEASE

Danila Di Majo, Emanuele Sinagra, Giovanni Tomasello, Attilio Ignazio Lo Monte, Marco Giammanco, Alida Abruzzo, Vincenzo Davide Palumbo, Angelo Leone, Giovanni Cassata, Provvidenza Damiani, Emanuele Sinagra, Luca Cicero, Giovanni Tomasello

Risultato della ricerca: Article

21 Citazioni (Scopus)

Abstract

Inflammatory Bowel disease (IBD), such as Crohn's disease and ulcerative colitis, are pathologies characterized by a chronic inflammation of the gastrointestinal tract. Their etiopathogenesis is not yet fully understood. Immune system and heat shock proteins (HSPs) dysfunctions are considered to be among the most likely causes of these diseases. Butyrate is a short-chain fatty acid produced by intestinal microflora. It has a trophic, benefical and protective role in the colonic mucosa, and it also induces changes in Hsp levels and localization. It may therefore be a valuable complementary therapeutic agent when used alongside trraditional drugs (mesalazine and corticosteroids) to treat the production of butyrate in the endoluminal environment may promote clinical remission in IBD patients. Due to these characteristics, there has been keen interest in the use of butyrate as a novel therapeutic supplement in the recent years. The current findings need to be validated through further clinical trials to better define the bbiomolecular dynamics of butyrate in the colonocytes of IBD patients.
Lingua originaleEnglish
pagine (da-a)24-35
Numero di pagine12
RivistaEuroMediterranean Biomedical Journal
Volume9
Stato di pubblicazionePublished - 2014

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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