The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

Sebastiano Bonventre, Gaspare Gulotta, Gianfranco Cocorullo, Marco Attard, Andrea Attard, Cristina Raspanti, Giuseppina Irene Melfa, Roberto Gullo, Sergio Mazzola

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

Purpose: Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors. Methods: A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Exclusion criteria were as follows: Gravesâ disease, malignancies requiring radioiodine therapy, post-surgical hypoparathyroidism, laryngeal nerve palsy, abnormal pre- and post-operative thyroid hormone levels, and BMI outside the normal range. Demographics; smoking and alcoholism addiction; cardiac, pulmonary, renal, and hepatic failure; diabetes; anxiety; and depression were recorded. The Brief Fatigue Inventory (BFI) was used to evaluate CA and its possible association with these comorbidities 6 and 12 months after thyroidectomy. Results: One hundred seventy-seven patients underwent total thyroidectomy (TT), 54 hemithyroidectomy (HT). Thirty-two patients were not recorded because of the onset of exclusion criteria. In the 6 months after thyroidectomy, in the TT group, 64 patients (36.16%) reported an impairment in the BFI score and only 1 in the TL group. The mean BFI score changed from 1.663(±1.191) to 2.16 (±11.148) in the TT group, from 1.584 (±1.371) to 1.171 (±1.093) in the TL group (p < 0.001). No further significant variations in BFI were reported 1 year after surgery. Conclusions: CA worsened after TT, but not after HT. Apart from operative procedure itself, no other risk factor was found be significantly associated with post-thyroidectomy asthenia. Further investigation is needed to determine the causes of CA.
Lingua originaleEnglish
pagine (da-a)1095-1102
Numero di pagine8
RivistaLANGENBECK'S ARCHIVES OF SURGERY
Volume402
Stato di pubblicazionePublished - 2017

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Asthenia
Thyroidectomy
Cohort Studies
Prospective Studies
Fatigue
Equipment and Supplies
Laryngeal Nerves
Hypoparathyroidism
Graves Disease
Operative Surgical Procedures
Liver Failure
Thyroid Hormones
Paralysis
Alcoholism
Renal Insufficiency
Comorbidity
Thyroid Gland
Reference Values
Anxiety
Heart Failure

All Science Journal Classification (ASJC) codes

  • Surgery

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The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study. / Bonventre, Sebastiano; Gulotta, Gaspare; Cocorullo, Gianfranco; Attard, Marco; Attard, Andrea; Raspanti, Cristina; Melfa, Giuseppina Irene; Gullo, Roberto; Mazzola, Sergio.

In: LANGENBECK'S ARCHIVES OF SURGERY, Vol. 402, 2017, pag. 1095-1102.

Risultato della ricerca: Article

Bonventre, S, Gulotta, G, Cocorullo, G, Attard, M, Attard, A, Raspanti, C, Melfa, GI, Gullo, R & Mazzola, S 2017, 'The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study', LANGENBECK'S ARCHIVES OF SURGERY, vol. 402, pagg. 1095-1102.
Bonventre, Sebastiano ; Gulotta, Gaspare ; Cocorullo, Gianfranco ; Attard, Marco ; Attard, Andrea ; Raspanti, Cristina ; Melfa, Giuseppina Irene ; Gullo, Roberto ; Mazzola, Sergio. / The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study. In: LANGENBECK'S ARCHIVES OF SURGERY. 2017 ; Vol. 402. pagg. 1095-1102.
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title = "The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study",
abstract = "Purpose: Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors. Methods: A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Exclusion criteria were as follows: Graves{\^a} disease, malignancies requiring radioiodine therapy, post-surgical hypoparathyroidism, laryngeal nerve palsy, abnormal pre- and post-operative thyroid hormone levels, and BMI outside the normal range. Demographics; smoking and alcoholism addiction; cardiac, pulmonary, renal, and hepatic failure; diabetes; anxiety; and depression were recorded. The Brief Fatigue Inventory (BFI) was used to evaluate CA and its possible association with these comorbidities 6 and 12{\^A} months after thyroidectomy. Results: One hundred seventy-seven patients underwent total thyroidectomy (TT), 54 hemithyroidectomy (HT). Thirty-two patients were not recorded because of the onset of exclusion criteria. In the 6{\^A} months after thyroidectomy, in the TT group, 64 patients (36.16{\%}) reported an impairment in the BFI score and only 1 in the TL group. The mean BFI score changed from 1.663({\^A}±1.191) to 2.16 ({\^A}±11.148) in the TT group, from 1.584 ({\^A}±1.371) to 1.171 ({\^A}±1.093) in the TL group (p{\^A} <{\^A} 0.001). No further significant variations in BFI were reported 1{\^A} year after surgery. Conclusions: CA worsened after TT, but not after HT. Apart from operative procedure itself, no other risk factor was found be significantly associated with post-thyroidectomy asthenia. Further investigation is needed to determine the causes of CA.",
keywords = "Chronic asthenia, Fatigue, Hemithyroidectomy, Surgery, Total thyroidectomy",
author = "Sebastiano Bonventre and Gaspare Gulotta and Gianfranco Cocorullo and Marco Attard and Andrea Attard and Cristina Raspanti and Melfa, {Giuseppina Irene} and Roberto Gullo and Sergio Mazzola",
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pages = "1095--1102",
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TY - JOUR

T1 - The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

AU - Bonventre, Sebastiano

AU - Gulotta, Gaspare

AU - Cocorullo, Gianfranco

AU - Attard, Marco

AU - Attard, Andrea

AU - Raspanti, Cristina

AU - Melfa, Giuseppina Irene

AU - Gullo, Roberto

AU - Mazzola, Sergio

PY - 2017

Y1 - 2017

N2 - Purpose: Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors. Methods: A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Exclusion criteria were as follows: Gravesâ disease, malignancies requiring radioiodine therapy, post-surgical hypoparathyroidism, laryngeal nerve palsy, abnormal pre- and post-operative thyroid hormone levels, and BMI outside the normal range. Demographics; smoking and alcoholism addiction; cardiac, pulmonary, renal, and hepatic failure; diabetes; anxiety; and depression were recorded. The Brief Fatigue Inventory (BFI) was used to evaluate CA and its possible association with these comorbidities 6 and 12 months after thyroidectomy. Results: One hundred seventy-seven patients underwent total thyroidectomy (TT), 54 hemithyroidectomy (HT). Thirty-two patients were not recorded because of the onset of exclusion criteria. In the 6 months after thyroidectomy, in the TT group, 64 patients (36.16%) reported an impairment in the BFI score and only 1 in the TL group. The mean BFI score changed from 1.663(±1.191) to 2.16 (±11.148) in the TT group, from 1.584 (±1.371) to 1.171 (±1.093) in the TL group (p < 0.001). No further significant variations in BFI were reported 1 year after surgery. Conclusions: CA worsened after TT, but not after HT. Apart from operative procedure itself, no other risk factor was found be significantly associated with post-thyroidectomy asthenia. Further investigation is needed to determine the causes of CA.

AB - Purpose: Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors. Methods: A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Exclusion criteria were as follows: Gravesâ disease, malignancies requiring radioiodine therapy, post-surgical hypoparathyroidism, laryngeal nerve palsy, abnormal pre- and post-operative thyroid hormone levels, and BMI outside the normal range. Demographics; smoking and alcoholism addiction; cardiac, pulmonary, renal, and hepatic failure; diabetes; anxiety; and depression were recorded. The Brief Fatigue Inventory (BFI) was used to evaluate CA and its possible association with these comorbidities 6 and 12 months after thyroidectomy. Results: One hundred seventy-seven patients underwent total thyroidectomy (TT), 54 hemithyroidectomy (HT). Thirty-two patients were not recorded because of the onset of exclusion criteria. In the 6 months after thyroidectomy, in the TT group, 64 patients (36.16%) reported an impairment in the BFI score and only 1 in the TL group. The mean BFI score changed from 1.663(±1.191) to 2.16 (±11.148) in the TT group, from 1.584 (±1.371) to 1.171 (±1.093) in the TL group (p < 0.001). No further significant variations in BFI were reported 1 year after surgery. Conclusions: CA worsened after TT, but not after HT. Apart from operative procedure itself, no other risk factor was found be significantly associated with post-thyroidectomy asthenia. Further investigation is needed to determine the causes of CA.

KW - Chronic asthenia

KW - Fatigue

KW - Hemithyroidectomy

KW - Surgery

KW - Total thyroidectomy

UR - http://hdl.handle.net/10447/246204

M3 - Article

VL - 402

SP - 1095

EP - 1102

JO - LANGENBECK'S ARCHIVES OF SURGERY

JF - LANGENBECK'S ARCHIVES OF SURGERY

SN - 1435-2443

ER -