TY - JOUR
T1 - The predictive role of C-reactive protein in subjects with hypertension and subclinical atherosclerosis
AU - Novo, Salvatore
AU - Rizzo, Manfredi
AU - Novo, Giuseppina
AU - Muratori, Ida Maria
AU - Coppola, Giuseppe
AU - Corrado, Egle
AU - Corrado, Egle
AU - Muratori, null
AU - Novo, null
AU - Coppola, Giuseppe
AU - Novo, Giuseppina
PY - 2009
Y1 - 2009
N2 - Background: Recent guidelines published by the joint European Society of
Hypertension/European Society of Cardiology have suggested the inclusion of
C-reactive protein (CRP) in the standard assessment of cardiovascular risk in
hypertensive patients, but few data are available on the role of CRP in patients
with carotid lesions.
Methods: We studied 472 patients, 236 with and 236 without hypertension,
sex- and age-matched, with and without early stages of atherosclerosis (e.g.
those with an asymptomatic intima–media thickness of >0.9 mm), the influence
of all the other traditional cardiovascular risk factors (e.g. older age, male
sex, obesity, diabetes, smoking habit, family history of coronary artery disease,
dyslipidaemia) and of high-sensitivity CRP levels on cerebrovascular and
cardiovascular events in a 5-year follow up.
Results: At the end of follow up, patients with hypertension had more events
than those without (25% vs 17%, P < 0.05). Proportional hazard analysis
revealed in the group of patients without hypertension the presence of baseline
carotid lesions (P = 0.02) as predictor of events. In patients with hypertension,
the presence of baseline carotid lesions (P = 0.04) and elevated CRP
levels (P = 0.02) predicted clinical events. Patients with hypertension also
showed a significant relationship between clinical events and quintiles of CRP
levels (P < 0.01).
Conclusion: Beyond the utility of high-sensitivity CRP levels in the prediction
of early and late stages of atherosclerosis and subsequently on its association
with clinical events, the therapeutic implications of these results remain to be
evaluated by further studies
AB - Background: Recent guidelines published by the joint European Society of
Hypertension/European Society of Cardiology have suggested the inclusion of
C-reactive protein (CRP) in the standard assessment of cardiovascular risk in
hypertensive patients, but few data are available on the role of CRP in patients
with carotid lesions.
Methods: We studied 472 patients, 236 with and 236 without hypertension,
sex- and age-matched, with and without early stages of atherosclerosis (e.g.
those with an asymptomatic intima–media thickness of >0.9 mm), the influence
of all the other traditional cardiovascular risk factors (e.g. older age, male
sex, obesity, diabetes, smoking habit, family history of coronary artery disease,
dyslipidaemia) and of high-sensitivity CRP levels on cerebrovascular and
cardiovascular events in a 5-year follow up.
Results: At the end of follow up, patients with hypertension had more events
than those without (25% vs 17%, P < 0.05). Proportional hazard analysis
revealed in the group of patients without hypertension the presence of baseline
carotid lesions (P = 0.02) as predictor of events. In patients with hypertension,
the presence of baseline carotid lesions (P = 0.04) and elevated CRP
levels (P = 0.02) predicted clinical events. Patients with hypertension also
showed a significant relationship between clinical events and quintiles of CRP
levels (P < 0.01).
Conclusion: Beyond the utility of high-sensitivity CRP levels in the prediction
of early and late stages of atherosclerosis and subsequently on its association
with clinical events, the therapeutic implications of these results remain to be
evaluated by further studies
UR - http://hdl.handle.net/10447/46867
M3 - Article
VL - 39
SP - 539
EP - 545
JO - Internal Medicine Journal
JF - Internal Medicine Journal
SN - 1444-0903
ER -